Ordered deployment of distinct ciliary beating machines in growing axonemes of vertebrate multiciliated cells.
Ordered deployment of distinct ciliary beating machines in growing axonemes of vertebrate multiciliated cells.
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DOI：
10.1016/j.diff.2023.03.001
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发表时间：
2023-05
期刊：
影响因子：
2.9
通讯作者：
Wallingford, John B.
中科院分区：
文献类型：
--
作者：
Lee, Chanjae;Ma, Yun;Tu, Fan;Wallingford, John B.
The beating of motile cilia requires the coordinated action of diverse machineries that include not only the axonemal dynein arms, but also the central apparatus, the radial spokes, and the microtubule inner proteins. These machines exhibit complex radial and proximodistal patterns in mature axonemes, but little is known about the interplay between them during motile ciliogenesis. Here, we describe and quantify the relative rates of axonemal deployment for these diverse cilia beating machineries during the final stages of differentiation of Xenopus epidermal multiciliated cells.
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