Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.
Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.
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DOI：
10.1016/j.ejca.2012.01.038
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发表时间：
2012-09
影响因子：
8.4
通讯作者：
Hung, Rayjean J.
中科院分区：
文献类型：
--
作者：
Cote, Michele L.;Liu, Mei;Bonassi, Stefano;Neri, Monica;Schwartz, Ann G.;Christiani, David C.;Spitz, Margaret R.;Muscat, Joshua E.;Rennert, Gad;Aben, Katja K.;Andrew, Angeline S.;Bencko, Vladimir;Bickeboeller, Heike;Boffetta, Paolo;Brennan, Paul;Brenner, Hermann;Duell, Eric J.;Fabianova, Eleonora;Field, John K.;Foretova, Lenka;Friis, Soren;Harris, Curtis C.;Holcatova, Ivana;Hong, Yun-Chul;Isla, Dolores;Janout, Vladimir;Kiemeney, Lambertus A.;Kiyohara, Chikako;Lan, Qing;Lazarus, Philip;Lissowska, Jolanta;Le Marchand, Loic;Mates, Dana;Matsuo, Keitaro;Mayordomo, Jose I.;McLaughlin, John R.;Morgenstern, Hal;Mueeller, Heiko;Orlow, Irene;Park, Bernard J.;Pinchev, Mila;Raji, Olaide Y.;Rennert, Hedy S.;Rudnai, Peter;Seow, Adeline;Stucker, Isabelle;Szeszenia-Dabrowska, Neonila;Teare, M. Dawn;Tjonnelan, Anne;Ugolini, Donatella;van der Heijden, Henricus F. M.;Wichmann, Erich;Wiencke, John K.;Woll, Penella J.;Yang, Ping;Zaridze, David;Zhang, Zuo-Feng;Etzel, Carol J.;Hung, Rayjean J.
肺癌的家族聚集在吸烟后存在。但是，家族史通过吸烟状况，组织学，相对类型和种族影响风险的程度尚未得到很好的描述。该合并分析包括24个在国际肺癌财团中进行的病例对照研究。每项研究都收集了发病/访谈，性别，种族/种族，吸烟，组织学和肺癌一级家族史的年龄。分析了来自24,380例肺癌病例和23,305例健康对照的数据。无条件的逻辑回归模型和广义估计方程用于估计优势比和95％的置信区间。
在调整吸烟和其他潜在混杂因素后，患有肺癌一级亲戚的患者的肺癌风险增加了1.51倍（95％CI：1.39，1.63）。调整后，该协会对兄弟姐妹的家族史（OR = 1.82，95％CI：1.62，2.05）最强。未发现组织学类型的修改效果。从不吸烟者表现出较低的肺癌家族病史（OR = 1.25，95％CI：1.03，1.52），对于患有兄弟姐妹的患者（OR = 1.44，95％CI：1.07，1.93），稍强稍强。调整。
从未吸烟者中的风险增加，并且对家族史对肺癌风险的影响的类似地位表明，肺癌的家族性聚集与吸烟相关的肺癌独立于肺癌。尽管遗传变异在肺癌病因中的作用仍有待充分的特征，但家族史评估可以立即获得，具有积极病史的人代表了较高的风险群体。
Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analyzed. Unconditional logistic regression models and generalized estimating equations were used to estimate odds ratios and 95% confidence intervals. Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in risk of lung cancer, after adjustment for smoking and other potential confounders(95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (OR=1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR=1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR=1.44, 95% CI: 1.07, 1.93), after adjustment. The increased risk among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those associated with cigarette smoking. While the role of genetic variation in the etiology of lung cancer remains to be fully characterized, family history assessment is immediately available and those with a positive history represent a higher risk group.
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影响因子：
10.3
作者：
Chang, ET;Smedby, KE;Adami, HO
通讯作者：
Adami, HO
影响因子：
3.8
作者：
Gallagher, Carla J.;Muscat, Joshua E.;Lazarus, Philip
通讯作者：
Lazarus, Philip
DOI：
10.3779/j.issn.1009-3419.2010.03.07
发表时间：
2010-03
期刊：
Zhongguo fei ai za zhi = Chinese journal of lung cancer
影响因子：
--
作者：
Gu J;Hua F;Zhong D;Chen J;Liu H;Zhou Q
通讯作者：
Zhou Q
影响因子：
3.8
作者：
Hassan, Manal M.;Phan, Alexandria;Yao, James C.
通讯作者：
Yao, James C.
影响因子：
11.2
作者：
Aldrich, Melinda C.;Selvin, Steve;Wiencke, John K.
通讯作者：
Wiencke, John K.