Global Efficiency of Structural Networks Mediates Cognitive Control in Mild Cognitive Impairment.
Global Efficiency of Structural Networks Mediates Cognitive Control in Mild Cognitive Impairment.
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DOI：
10.3389/fnagi.2016.00292
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发表时间：
2016
影响因子：
4.8
通讯作者：
O'Sullivan MJ
中科院分区：
文献类型：
--
作者：
Berlot R;Metzler-Baddeley C;Ikram MA;Jones DK;O'Sullivan MJ
背景：认知控制既与个体脑束的微结构有关，也与全脑网络结构有关，但它们在健康和疾病中的相对贡献尚不清楚。目的：探讨老年人和轻度认知障碍(MCI)患者局部脑白质束损伤和整体网络结构破坏对认知控制的影响。材料和方法：对25例MCI患者和20例年龄、性别、智力匹配的健康志愿者进行3T结构磁共振成像(MRI)检查。认知控制和情景记忆通过既定的测试进行评估。结构网络图由基于弥散磁共振成像的全脑纤维束成像构建。他们的整体测量是用图论计算的。回归模型利用全球网络指标和特定连接的微观结构(已知对每个领域至关重要)来预测认知分数。结果：MCI降低了网络的全局效率和平均聚类系数。认知控制与全局网络拓扑结构有关。相比之下，情节记忆只与个体的时间段相关。认知控制和网络拓扑之间的关系通过在回归模型中加入单径路测量而减弱，这与部分中介作用一致。MCI组的中介效应强于健康志愿者，可解释扣带微结构对认知控制绩效影响的23%-36%。网络聚集性在两组患者的脑束微结构与认知控制之间的关系中起着重要的中介作用。结论：关键连接状态和大规模网络拓扑结构对认知控制在MCI中的维持都很重要。在MCI患者中，通过大规模网络进行调解比健康志愿者更重要。这种效应是特定领域的，对认知控制是正确的，但对情景记忆则不是。改善认知控制的干预措施需要同时解决局部回路和全球网络架构的功能障碍，才能发挥最大的效果。
Background: Cognitive control has been linked to both the microstructure of individual tracts and the structure of whole-brain networks, but their relative contributions in health and disease remain unclear. Objective: To determine the contribution of both localized white matter tract damage and disruption of global network architecture to cognitive control, in older age and Mild Cognitive Impairment (MCI). Materials and Methods: Twenty-five patients with MCI and 20 age, sex, and intelligence-matched healthy volunteers were investigated with 3 Tesla structural magnetic resonance imaging (MRI). Cognitive control and episodic memory were evaluated with established tests. Structural network graphs were constructed from diffusion MRI-based whole-brain tractography. Their global measures were calculated using graph theory. Regression models utilized both global network metrics and microstructure of specific connections, known to be critical for each domain, to predict cognitive scores. Results: Global efficiency and the mean clustering coefficient of networks were reduced in MCI. Cognitive control was associated with global network topology. Episodic memory, in contrast, correlated with individual temporal tracts only. Relationships between cognitive control and network topology were attenuated by addition of single tract measures to regression models, consistent with a partial mediation effect. The mediation effect was stronger in MCI than healthy volunteers, explaining 23-36% of the effect of cingulum microstructure on cognitive control performance. Network clustering was a significant mediator in the relationship between tract microstructure and cognitive control in both groups. Conclusion: The status of critical connections and large-scale network topology are both important for maintenance of cognitive control in MCI. Mediation via large-scale networks is more important in patients with MCI than healthy volunteers. This effect is domain-specific, and true for cognitive control but not for episodic memory. Interventions to improve cognitive control will need to address both dysfunction of local circuitry and global network architecture to be maximally effective.
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