Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials.
Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials.
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DOI：
10.1016/j.bioactmat.2023.04.013
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发表时间：
2023-09
影响因子：
18.9
通讯作者：
Shimizu, Emi
中科院分区：
文献类型：
--
作者：
Duncan, Henry F.;Kobayashi, Yoshifumi;Kearney, Michaela;Shimizu, Emi
关键词：
这篇以观点为导向的综述论文强调了在牙髓治疗（VPT）中进行新型转化研究的必要性，但也讨论了将证据转化为临床证据的挑战。传统的牙科治疗是昂贵的，侵入性的，并且依赖于对牙科疾病的过时的机械理解，而不是采用利用细胞活性和再生能力的生物学观点。最近的研究集中在开发微创生物基“填充物”，以保护牙髓;研究正在将范式从昂贵的高科技牙科，高失败率，转移到针对生物过程的智能牙科。目前的VPT通过在材料依赖性过程中招募成牙本质细胞样细胞来促进修复。因此，开发针对牙本质牙髓复合体再生过程的下一代生物材料存在令人兴奋的机会。本文分析了最近的研究，使用药理学抑制剂治疗靶向组蛋白脱乙酰酶（HDAC）酶在牙髓细胞（DPC），刺激促再生作用与有限的活力损失。因此，HDAC抑制剂具有通过影响细胞过程以最小的副作用来增强低浓度下生物材料驱动的组织反应的潜力，从而提供了开发局部放置的廉价生物诱导盖髓材料的机会。尽管取得了积极的成果，但这些创新的临床转化需要企业应对监管障碍，牙科行业优先事项，并建立强大的学术/行业合作伙伴关系。这篇以观点为导向的综述论文的目的是讨论治疗靶向表观遗传修饰作为局部VPT策略的一部分在治疗受损牙髓中的潜在作用，同时考虑表观遗传疗法或其他“智能”VPT治疗的临床开发的下一步，材料考虑，挑战和未来。阐明了对下一代靶向活髓生物材料的需求，以改善组织反应和治疗结果。提供支持HDACi作为生物活性成分用于盖髓材料以刺激修复的证据。讨论了最近的立法的发展，接触牙髓组织的“智能”牙科净化的影响。
This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment (VPT), but also discusses the challenges in translating evidence to clinics. Traditional dentistry is expensive, invasive and relies on an outmoded mechanical understanding of dental disease, rather than employing a biological perspective that harnesses cell activity and the regenerative-capacity. Recent research has focussed on developing minimally-invasive biologically-based ‘fillings’ that preserve the dental pulp; research that is shifting the paradigm from expensive high-technology dentistry, with high failure rates, to smart restorations targeted at biological processes. Current VPTs promote repair by recruiting odontoblast-like cells in a material-dependent process. Therefore, exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp complex. This article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase (HDAC) enzymes in dental-pulp-cells (DPCs) that stimulate pro-regenerative effects with limited loss of viability. Consequently, HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects, providing an opportunity to develop a topically-placed, inexpensive bio-inductive pulp-capping material. Despite positive results, clinical translation of these innovations requires enterprise to counteract regulatory obstacles, dental-industry priorities and to develop strong academic/industry partnerships. The aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp, while considering the next steps, material considerations, challenges and future for the clinical development of epigenetic therapeutics or other ‘smart’ restorations in VPT. Illustrates the need for next-generation targeted vital pulp biomaterials to improve tissue response and treatment outcome. Provides evidence supporting the use of HDACi as a bioactive component to pulp capping materials to stimulate repair.. Discusses the implications of recent legislation on the development of ‘smart’ dental restorations that contact pulp tissue.
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影响因子：
5.1
作者：
Almushayt, A;Narayanan, K;George, A
通讯作者：
George, A
影响因子：
5
作者：
Aeinehchi, M;Eslami, B;Saffar, AS
通讯作者：
Saffar, AS
影响因子：
7.6
作者：
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通讯作者：
Zehnder M
影响因子：
2.5
作者：
Machado MAAM;Stafuzza TC;Vitor LLR;da Costa SA;da Costa SM;Neto NL;Oliveira TM
通讯作者：
Oliveira TM
影响因子：
7.6
作者：
BUTLER, WT;MIKULSKI, A;UYENO, S
通讯作者：
UYENO, S