Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China
Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China
复制标题
中国男囚犯催产素受体基因、儿童期虐待与边缘性人格障碍特征
DOI：
10.1186/s12888-020-02710-0
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发表时间：
2020-06
期刊：
影响因子：
4.4
通讯作者：
Ning Zhang
中科院分区：
文献类型：
--
作者：
Min Zhang;Na Liu;Haocheng Chen;Ning Zhang
背景：边缘型人格障碍（BPD）是由多种生物和环境因素引起的。越来越多的证据表明，儿童期虐待是BPD发展的危险环境因素，但对BPD遗传病理学的研究仍处于早期阶段，对催产素受体（OXTR）基因的了解甚少。本研究旨在进一步探讨OXTR基因多态性与儿童期虐待对BPD风险的交互作用。方法：在1804名中国汉族男性服刑人员中，765名患有BPD或反社会人格障碍（ASPD）或高度冲动或暴力犯罪的服刑人员被认为是高危服刑人员，并纳入本研究。儿童期虐待、BPD、反社会人格障碍（ASPD）和冲动性采用自评问卷进行测量。采集外周静脉血进行基因型检测。结果：分析显示BP组（有BPD特征的囚犯）比非BP组有更高的rs53576 AA基因型频率和rs237987 AA基因型频率，但经Bonferroni校正后，统计学意义消失。儿童期虐待总分、情感虐待和忽视对BPD风险有正向预测作用。在高风险样本中，rs53576 GG基因型携带者在较高水平的身体虐待和性虐待时具有较高的BPD评分，而在较低水平的身体虐待和性虐待时具有较低的BPD评分。结论：研究结果表明OXTR基因变异和儿童期虐待之间的相互作用是BPD发展的重要机制。OXTR基因的调节作用为基因可塑性提供了证据。
Abstract.Background.Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk..Methods.Among the 1804 Chinese Han male inmates, 765 inmates who had BPD or antisocial personality disorder (ASPD) or highly impulsive or violent crime were considered as high-risk inmates and included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test..Results.Analyses revealed that the BP group (inmates with BPD features) had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group, while the statistical significances were lost after Bonferroni correction. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse..Conclusions.The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.
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影响因子：
11
作者：
通讯作者：
--
DOI：
10.1037/per0000265
发表时间：
2017-11
期刊：
Personality Disorders: Theory, Research, and Treatment
影响因子：
--
作者：
Gretchen Kurdziel;Stephanie B. Kors;J. Macfie
通讯作者：
Gretchen Kurdziel;Stephanie B. Kors;J. Macfie
影响因子：
1.8
作者：
G. Parker;S. McCraw;Adam Bayes
通讯作者：
G. Parker;S. McCraw;Adam Bayes
影响因子：
5.3
作者：
通讯作者：
--
影响因子：
1.7
作者：
Kolla NJ;Vinette SA
通讯作者：
Vinette SA