Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures.
Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures.
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DOI：
10.1002/dvdy.22048
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发表时间：
2009-09
影响因子：
2.5
通讯作者：
Rosen, Vicki
中科院分区：
文献类型：
--
作者：
Gamer, Laura W.;Cox, Karen;Carlo, Joelle M.;Rosen, Vicki
骨形态发生蛋白-3（BMP）已被鉴定为骨骼中的负调节因子，因为缺乏BMP 3的小鼠骨量增加。为了进一步了解BMP 3是如何介导骨形成的，我们使用I型胶原启动子创建了过表达BMP 3的转基因小鼠。BMP 3转基因小鼠显示自发性肋骨骨折，首次在E17.0检测到。骨折是由于骨膜分化缺陷和晚期肥大软骨细胞导致骨皮质变薄，矿化减少。由于BMP 3通过ActRIIB调节BMP和激活素信号传导，我们检查了ActRIIB受体敲除小鼠的肋骨，发现它们在后期软骨形成和矿化方面存在缺陷，与BMP 3转基因小鼠相似。这些数据表明，BMP 3通过改变软骨细胞和骨膜中ActRIIB的信号传导在骨骼中发挥其作用，这导致骨领形成缺陷和晚期肥大软骨细胞成熟，导致矿化减少和骨减少。
Bone morphogenetic protein-3 (BMP) has been identified as a negative regulator in the skeleton as mice lacking BMP3 have increased bone mass. To further understand how BMP3 mediates bone formation, we created transgenic mice overexpressing BMP3 using the type I collagen promoter. BMP3 transgenic mice displayed spontaneous rib fractures that were first detected at E17.0. The fractures were due to defects in differentiation of the periosteum and late hypertrophic chondrocytes resulting in thinner cortical bone with decreased mineralization. As BMP3 modulates BMP and activin signaling through ActRIIB, we examined the ribs of ActRIIB receptor knockout mice and found they had defects in late chondrogenesis and mineralization similar to BMP3 transgenic mice. These data suggest that BMP3 exerts its effects in the skeleton by altering signaling through ActRIIB in chondrocytes and the periosteum, and this results in defects in bone collar formation and late hypertrophic chondrocyte maturation leading to decreased mineralization and less bone.
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通过 Bmp5 基因中的模块化调控元件塑造骨骼生长。
影响因子：
4.5
作者：
Guenther C;Pantalena-Filho L;Kingsley DM
通讯作者：
Kingsley DM
DOI：
10.1073/pnas.0503617102
发表时间：
2005-12-13
影响因子：
11.1
作者：
Kobayashi, T;Lyons, KM;Kronenberg, HM
通讯作者：
Kronenberg, HM
DOI：
10.1073/pnas.83.23.8819
发表时间：
1986-12-01
影响因子：
11.1
作者：
OLDBERG, A;FRANZEN, A;HEINEGARD, D
通讯作者：
HEINEGARD, D
影响因子：
4.8
作者：
Gaddy-Kurten, D;Coker, JK;Manolagas, SC
通讯作者：
Manolagas, SC
影响因子：
2.5
作者：
Gamer, Laura W.;Ho, Victoria;Rosen, Vicki
通讯作者：
Rosen, Vicki