Peripheral monocyte count is associated with case fatality after intracerebral hemorrhage.
Peripheral monocyte count is associated with case fatality after intracerebral hemorrhage.
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DOI：
10.1016/j.jstrokecerebrovasdis.2013.09.006
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发表时间：
2014-02
影响因子：
2.5
通讯作者：
Woo, Daniel
中科院分区：
文献类型：
--
作者：
Adeoye, Opeolu;Walsh, Kyle;Woo, Jessica G.;Haverbusch, Mary;Moomaw, Charles J.;Broderick, Joseph P.;Kissela, Brett M.;Kleindorfer, Dawn;Flaherty, Matthew L.;Woo, Daniel
白细胞增多与脑出血（ICH）后的出血量和早期神经功能恶化有关。我们检测了总白细胞（WBC）计数、绝对单核细胞（AMC）和中性粒细胞（ANC）计数作为人类脑出血的潜在的、现成的预后生物标志物。在一项回顾性研究中，年龄≥18岁的成年患者在2008年7月至2009年12月症状出现后12小时内在两家当地医院中的一家就诊。确定了人口统计学、格拉斯哥昏迷量表（GCS）、脑出血体积、脑出血位置和30天病死率。测定白细胞总数、ANC、AMC和血红蛋白浓度。分别使用线性和逻辑回归来评估与基线脑出血体积（对数转换）和30天病死率相关的因素。186例患者平均（±SD）年龄为67.3±14.8岁，男性占51%，黑人占22%。中位[IQR]脑出血体积为12.8 [4.9,29.4]ml。在调整患者年龄和初始血红蛋白后，较高的初始WBC计数（p=0.0009）和较高的ANC （p=0.006）与较高的脑出血体积相关，而AMC则不相关（p=0.4）。在调整患者年龄、GCS、脑室内出血（+/−）、卒中位置和脑出血容量后，基线AMC与30天病死率较高的几率相关（OR 2.26, 95% CI 1.10-4.65, p=0.03）。AMC与脑出血后较高的30天病死率的关联是一种假设。鉴于AMC与脑出血体积之间缺乏相关性，AMC可能导致脑出血后的继发性损伤（血肿扩张和/或脑水肿）。
Leukocytosis is associated with hemorrhage volume and early neurological deterioration after intracerebral hemorrhage (ICH). We examined total white blood cell (WBC) count and absolute monocyte (AMC) and neutrophil (ANC) counts as potential readily available prognostic biomarkers in human ICH. In a retrospective study, adult patients aged ≥ 18 years who presented to one of two local hospitals with nontraumatic ICH from July 2008 to December 2009 within 12 hours of symptom onset were identified. Demographics, Glasgow coma scale (GCS), ICH volume, ICH location, and 30-day case-fatality rates were determined. Total WBC count, ANC, AMC, and hemoglobin concentration were determined. Linear and logistic regression were used to evaluate factors associated with baseline ICH volume (log transformed) and 30-day case-fatality, respectively. Of the 186 patients, mean (±SD) age was 67.3±14.8 years, 51% were male, 22% were black. Median [IQR] ICH volume was 12.8 [4.9, 29.4] ml. After adjusting for patient age and initial hemoglobin, higher initial WBC count (p=0.0009) and higher ANC (p=0.006) were associated with higher ICH volume, whereas AMC was not (p=0.4). After adjusting for patient age, GCS, intraventricular hemorrhage (+/−), stroke location, and ICH volume, baseline AMC was associated with greater odds of 30-day case-fatality (OR 2.26, 95% CI 1.10–4.65, p=0.03). The association of AMC with higher 30-day case-fatality after ICH is hypothesis generating. Given the lack of association between presenting AMC and ICH volume, AMC may contribute to secondary injury after ICH (hematoma expansion and/or cerebral edema).
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影响因子：
3.6
作者：
Adeoye, Opeolu;Haverbusch, Mary;Flaherty, Matthew L.
通讯作者：
Flaherty, Matthew L.
影响因子：
2.8
作者：
Gratchev, Alexei;Sobenin, Igor;Kzhyshkowska, Julia
通讯作者：
Kzhyshkowska, Julia
影响因子：
8.8
作者：
Kumar, Monisha A.;Rost, Natalia S.;Rosand, Jonathan
通讯作者：
Rosand, Jonathan
影响因子：
9.3
作者：
Agnihotri S;Czap A;Staff I;Fortunato G;McCullough LD
通讯作者：
McCullough LD
影响因子：
8.3
作者：
BRODERICK, JP;BROTT, TG;HUSTER, G
通讯作者：
HUSTER, G