Human papillomavirus persistence in young unscreened women, a prospective cohort study.
Human papillomavirus persistence in young unscreened women, a prospective cohort study.
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DOI：
10.1371/journal.pone.0027937
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Bekkers RL
中科院分区：
文献类型：
--
作者：
Schmeink CE;Melchers WJ;Siebers AG;Quint WG;Massuger LF;Bekkers RL
To evaluate hr-HPV persistence and associated risk factors in a prospective cohort of young unscreened women. Additionally, the relation between hr-HPV status and cytology/histology results is examined. Two year follow-up of 235 out of 2065 young women (18–29 years), participating in a large, one year epidemiological study, with questionnaires, self-collected cervico-vaginal samples (Vibabrush), and SPF10LiPA for HPV detection. Only women hr-HPV positive at sample month 12 were invited for a second year of follow-up. After study follow-up, available cytology/histology data were requested from PALGA (the national network and registry of histo- and cytopathology in The Netherlands). These data were compared with available cytology/histology data of the month 12 hr-HPV negative women from the same cohort. 44.1% of the hr-HPV types detected at study month 12, persisted during follow-up. HPV types 45, 31, 16 and 18 were most likely to persist with percentages of 60.0%, 56.8%, 54.4%,and 50.0%, respectively. Compared to newly detected infections at month 12, infections present since 6 months or baseline had an increased risk to persist (OR 3.09 [95% CI: 1.74–5.51] and OR 4.99 [95% CI: 2.67–9.32], respectively). Other co-factors influencing persistence were, multiple HPV infections, smoking and multiple lifetime sexual partners. The percentage of women with a HSIL/CIN2+ (12.1%) in the persistent HPV group, was not significantly different (p = 0.107) from the 5.3% of the women who cleared the hr-HPV infection, but was significantly (p 0.000) higher than to the 1.6% of women in the hr-HPV negative control group. We showed that HPV genotype, multiple infections, smoking, and multiple lifetime sexual partners are co-factors that increase the risk of hr-HPV persistency. Most importantly, we showed that hr-HPV infections are more likely to persist the longer they have been present and that women with a persistent hr-HPV infection have a high risk of HSIL/CIN2+ development.
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影响因子：
3.7
作者：
Lenselink CH;Melchers WJ;Quint WG;Hoebers AM;Hendriks JC;Massuger LF;Bekkers RL
通讯作者：
Bekkers RL
影响因子：
12.7
作者：
Nielsen, Ann;Kjaer, Susanne K.;Iftner, Thomas
通讯作者：
Iftner, Thomas
影响因子：
12.7
作者：
Iftner, Thomas;Eberle, Sonja;Straube, Anja-Natascha
通讯作者：
Straube, Anja-Natascha
影响因子：
8.8
作者：
Muñoz, N
通讯作者：
Muñoz, N
影响因子：
3.8
作者：
Kulmala, Satu-Maria A.;Shabalova, Irena P.;Syrjanen, Stina M.
通讯作者：
Syrjanen, Stina M.