Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials.
Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials.
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DOI：
10.1021/ja108568g
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发表时间：
2010-12-22
影响因子：
15
通讯作者：
DeSimone, Joseph
中科院分区：
文献类型：
--
作者：
Parrott, Matthew C.;Luft, J. Chris;Byrne, James D.;Fain, John H.;Napier, Mary E.;DeSimone, Joseph
响应性高分子生物材料可以通过体内的局部环境触发降解。有限数量的生物材料可以精确控制降解速度和被困物质的释放速度，并产生本质上无毒的材料。在此，我们设计了基于硅醚化学的无毒酸敏感生物材料。大量的硅醚交联剂被合成并成型成相关的医疗器械，包括特洛伊木马颗粒、缝合线和支架。由此产生的装置被设计成在已知存在于肿瘤组织、炎症组织和病变细胞中的酸性条件下降解。硅醚化学的实现可以精确地控制降解速度，并根据硅原子周围的空间体积，提供可以在数小时、数天、数周或数月的过程中降解的设备。这些新型材料可用于多种生物医学应用，包括药物输送、组织修复和普通外科手术。
Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of biomaterials provide precise control over the rate of degradation, the release rate of entrapped cargo, and yield a material that is intrinsically non-toxic. Here we design non-toxic acid-sensitive biomaterials based on silyl ether chemistry. A host of silyl ether cross-linkers were synthesized and molded into relevant medical devices including Trojan horse particles, sutures, and stents. The resulting devices were engineered to degrade under acidic conditions known to exist in tumor tissue, inflammatory tissue, and within diseased cells. The implementation of silyl ether chemistry gave precise control over the rate of degradation, and depending upon the steric bulk around the silicon atom, afforded devices that could degrade over the course of hours, days, weeks, or months. These novel materials could be useful for numerous biomedical applications including drug-delivery, tissue repair, and general surgery.
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影响因子：
2.9
作者：
Miller, CR;Bondurant, B;O'Brien, DF
通讯作者：
O'Brien, DF
DOI：
10.1002/jbm.820170612
发表时间：
1983-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
CHU, CC;WILLIAMS, DF
通讯作者：
WILLIAMS, DF
DOI：
10.1016/0006-291x(81)91644-2
发表时间：
1981-01-01
影响因子：
3.1
作者：
SHEN, WC;RYSER, HJP
通讯作者：
RYSER, HJP
可用于长循环纳米颗粒的可覆盖涂料。
影响因子：
3.7
作者：
Romberg, Birgit;Hennink, Wim E.;Storm, Gert
通讯作者：
Storm, Gert
影响因子：
10.8
作者：
Nunes J;Herlihy KP;Mair L;Superfine R;DeSimone JM
通讯作者：
DeSimone JM