The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan.
The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan.
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在整个生命周期内，纵向皮层体积变化的遗传组织稳定。
DOI：
10.7554/elife.66466
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发表时间：
2021-06-28
期刊：
影响因子：
7.7
通讯作者：
Walhovd KB
中科院分区：
文献类型：
--
作者：
Fjell AM;Grydeland H;Wang Y;Amlien IK;Bartres-Faz D;Brandmaier AM;Düzel S;Elman J;Franz CE;Håberg AK;Kietzmann TC;Kievit RA;Kremen WS;Krogsrud SK;Kühn S;Lindenberger U;Macía D;Mowinckel AM;Nyberg L;Panizzon MS;Solé-Padullés C;Sørensen Ø;Westerhausen R;Walhovd KB
大脑皮层的发育和衰老表现出相似的地形组织，并受相同的基因控制。目前尚不清楚皮层下区域是否也是如此，它们遵循着根本不同的个体发生和系统发生原则。我们通过评估共同发育的大脑区域在多大程度上在一生中继续变化，来测试基因控制的神经发育过程可以在一生中被追踪的假设。通过对6000多张大脑的纵向核磁共振成像进行分析，我们利用图论识别出协调发展的5个集群，并将其索引为大脑结构中相关体积变化的模式。在胚胎大脑发育过程中，这些簇倾向于沿着颅轴排列，表明从产前阶段开始就存在连续性，并且与认知相关。通过独立的纵向数据集，我们证明了发育集群在整个生命中都是保守的。基于双胞胎的遗传相关性揭示了每个集群中控制变化的不同基因集。基于单核苷酸多态性的38,127个横断面mri分析显示了类似的遗传体积-体积相关性模式。总之，皮质下变化的协调性符合寿命连续性和遗传组织的基本原则。
Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume–volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
影响因子：
2.6
作者：
McArdle, John J.;Plassman, Brenda L.
通讯作者：
Plassman, Brenda L.