A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.
A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.
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DOI：
10.1007/s10519-009-9272-1
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发表时间：
2009-09
影响因子：
2.6
通讯作者：
Plassman, Brenda L.
中科院分区：
文献类型：
--
作者：
McArdle, John J.;Plassman, Brenda L.
关键词：
先前的研究表明，认知能力随着年龄的变化而具有不同的生物识别模式。在这里，我们检查了 6,000 多对双胞胎的情景记忆（回忆单词）的变化，这些双胞胎最初年龄在 59-75 岁之间，随后在 12 年内重新评估了多达 3 次。在横断面分析中，教育程度的差异可以通过强烈的加性遗传影响（~43%）以及与年龄无关的共同家庭影响（~35%）来解释。单词回忆任务的纵向表型分析显示，随着年龄的增长，系统性线性下降，但受到教育和重新测试的积极影响。纵向生物特征估计得出：（a）非共享环境影响和瞬时测量误差（〜50％）的分离：（b）该潜在曲线的强加性遗传成分（60岁时〜70％）随着年龄的增长而增加，到90岁时达到约90％。（c）共享家庭环境的次要影响（60岁时〜17％）在75岁时有效消除。（d）非共享环境影响在寿命的大部分时间（70 岁时达到峰值 42%），但其相对作用在 75 岁之后逐渐减弱。
Previous research has shown cognitive abilities to have different biometric patterns of age-changes. Here we examined the variation in episodic memory (Words Recalled) for over 6,000 twin pairs who were initially aged 59-75, and were subsequently re-assessed up to three more times over 12 years. In cross-sectional analyses, variation in Education was explained by strong additive genetic influences (~43%) together with shared family influences (~35%) that were independent of age. The longitudinal phenotypic analysis of the Word Recall task showed systematic linear declines over age, but with positive influences of Education and Retesting. The longitudinal biometric estimation yielded: (a) A separation of non-shared environmental influences and transient measurement error (~50%): (b) Strong additive genetic components of this latent curve (~70% at age 60) with increases over age that reach about 90% by age 90. (c) The minor influences of shared family environment (~17% at age 60) were effectively eliminated by age 75. (d) Non-shared environmental effects play an important role over most of the life-span (peak of 42% at age 70) but their relative role diminishes after age 75.
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影响因子：
2.6
作者：
Finkel, D;Pedersen, NL;Svartengren, M
通讯作者：
Svartengren, M
影响因子：
2.6
作者：
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通讯作者：
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通讯作者：
OOI, WL
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通讯作者：
JARVIK, LF