Human blood T(fr) cells are indicators of ongoing humoral activity not fully licensed with suppressive function.
Human blood T(fr) cells are indicators of ongoing humoral activity not fully licensed with suppressive function.
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DOI：
10.1126/sciimmunol.aan1487
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发表时间：
2017-08-11
影响因子：
24.8
通讯作者：
Graca L
中科院分区：
文献类型：
--
作者：
Fonseca VR;Agua-Doce A;Maceiras AR;Pierson W;Ribeiro F;Romão VC;Pires AR;da Silva SL;Fonseca JE;Sousa AE;Linterman MA;Graca L
生发中心（GC）反应由T滤泡辅助细胞（Tfh）和T滤泡调节细胞（Tfr）控制，对产生高亲和力抗体至关重要。虽然人体循环和组织Tfh细胞的生物学已经建立，但血液和组织Tfr细胞（定义为CXCR5+Foxp3+ T细胞）之间的关系仍然难以捉摸。在这里，我们发现血液Tfr细胞在Sjögren综合征中增加，特别是在自身抗体滴度高的患者中，以及在流感疫苗接种后的健康受试者中。然而，血液Tfr细胞与体液反应相关，尽管能够抑制t细胞增殖，但它们缺乏完全的b细胞抑制能力。血液Tfr细胞具有naïve-like表型，尽管它们在人类胸腺或脐带血中不存在。在这里，我们发现这些细胞在T-B相互作用之前在周围淋巴组织中产生，因为它们在b细胞缺陷患者中保持不变。因此，在人类病理中，血液中的CXCR5+Foxp3+ T细胞表明正在进行的体液活性，但不是称职的Tfr细胞。
Germinal center (GC) responses are controlled by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells and are crucial for the generation of high affinity antibodies. Although the biology of human circulating and tissue Tfh cells has been established, the relationship between blood and tissue Tfr cells, defined as CXCR5+Foxp3+ T cells, remains elusive. Here, we found that blood Tfr cells are increased in Sjögren syndrome, especially in patients with high autoantibody titres, as well as in healthy subjects upon influenza vaccination. While, blood Tfr cells correlated with humoral responses they lack full B-cell suppressive capacity, despite being able to suppress T-cell proliferation. Blood Tfr cells have a naïve-like phenotype, although they are absent from human thymus or cord blood. Here, we found these cells were generated in peripheral lymphoid tissues prior to T-B interaction, as they are maintained in B-cell deficient patients. Therefore, blood CXCR5+Foxp3+ T cells in human pathology indicate ongoing humoral activity, but are not competent Tfr cells.
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DOI：
10.1016/j.jaci.2015.05.036
发表时间：
2015-10
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Ma CS;Wong N;Rao G;Avery DT;Torpy J;Hambridge T;Bustamante J;Okada S;Stoddard JL;Deenick EK;Pelham SJ;Payne K;Boisson-Dupuis S;Puel A;Kobayashi M;Arkwright PD;Kilic SS;El Baghdadi J;Nonoyama S;Minegishi Y;Mahdaviani SA;Mansouri D;Bousfiha A;Blincoe AK;French MA;Hsu P;Campbell DE;Stormon MO;Wong M;Adelstein S;Smart JM;Fulcher DA;Cook MC;Phan TG;Stepensky P;Boztug K;Kansu A;İkincioğullari A;Baumann U;Beier R;Roscioli T;Ziegler JB;Gray P;Picard C;Grimbacher B;Warnatz K;Holland SM;Casanova JL;Uzel G;Tangye SG
通讯作者：
Tangye SG
影响因子：
15.9
作者：
Lim, HW;Hillsamer, P;Kim, CH
通讯作者：
Kim, CH
影响因子：
30.5
作者：
Sage PT;Ron-Harel N;Juneja VR;Sen DR;Maleri S;Sungnak W;Kuchroo VK;Haining WN;Chevrier N;Haigis M;Sharpe AH
通讯作者：
Sharpe AH
影响因子：
17.1
作者：
Bentebibel SE;Lopez S;Obermoser G;Schmitt N;Mueller C;Harrod C;Flano E;Mejias A;Albrecht RA;Blankenship D;Xu H;Pascual V;Banchereau J;Garcia-Sastre A;Palucka AK;Ramilo O;Ueno H
通讯作者：
Ueno H
影响因子：
32.4
作者：
He, Jing;Tsai, Louis M.;Yu, Di
通讯作者：
Yu, Di