Mechanism of HIV-1 viral protein R-induced apoptosis.
Mechanism of HIV-1 viral protein R-induced apoptosis.
复制标题
HIV-1病毒蛋白R诱导细胞凋亡的机制。
DOI：
10.1016/s0006-291x(03)00631-4
复制
发表时间：
2003
影响因子：
3.1
通讯作者：
D. Weiner
中科院分区：
文献类型：
--
作者：
K. Muthumani;A. Y. Choo;D. Hwang;M. Chattergoon;Nathanael N Dayes;Donghui Zhang;Mark D. Lee;U. Duvvuri;D. Weiner
The paradigm of HIV-1 infection includes the diminution of CD4+T cells, loss of immune function, and eventual progression to AIDS. However, the mechanisms that drive host T cell depletion remain elusive. One HIV protein thought to participate in this destructive cascade is the Vpr gene product. Accordingly, we review the biology of the HIV-1 viral protein R (Vpr) an apoptogenic HIV-1 accessory protein that is packaged into the virus particle. In this review we focus specifically on Vpr’s ability to induce host cell apoptosis. Recent evidence suggests that Vpr implements a unique mechanism to drive host cell apoptosis, by directly depolarizing the mitochondria membrane potential. Vpr’s attack on the mitochondria results in release of cytochrome c resulting in activation of the caspase 9 pathway culminating in the activation of caspase 3 and the downstream events of apoptosis. Vpr may interact with the adenine nucleotide translocator (ANT) to prompt this cascade. The role of Vpr-induced apoptosis in HIV pathogenesis is considered.
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DOI：
10.1073/pnas.95.7.3419
发表时间：
1998-03-31
影响因子：
11.1
作者：
Mahalingam, S;Ayyavoo, V;Weiner, DB
通讯作者：
Weiner, DB
影响因子：
56.9
作者：
Poon, B;Grovit-Ferbas, K;Chen, ISY
通讯作者：
Chen, ISY
影响因子：
56.9
作者：
Wang, CY;Mayo, MW;Baldwin, AS
通讯作者：
Baldwin, AS
影响因子：
10.5
作者：
Marie A. Vodicka;D. Koepp;P. Silver;M. Emerman
通讯作者：
Marie A. Vodicka;D. Koepp;P. Silver;M. Emerman
影响因子：
16
作者：
Yang, XL;Chang, HY;Baltimore, D
通讯作者：
Baltimore, D