Human Skin Aging and the Anti-Aging Properties of Retinol.
Human Skin Aging and the Anti-Aging Properties of Retinol.
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DOI：
10.3390/biom13111614
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发表时间：
2023-11-04
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
皮肤是人体中最广泛和最丰富的组织。像许多器官一样，随着年龄的增长，人类皮肤的表皮和真皮都会逐渐萎缩。这主要归因于表皮干细胞数量的减少和胶原蛋白的减少，胶原蛋白是人体的主要结构蛋白。由于老化过程而在表皮和真皮中发生的改变导致皮肤的结构和功能的破坏。这创造了一个有利于与年龄相关的皮肤状况的微环境，例如受损的皮肤屏障，减缓伤口愈合和皮肤癌的发病。这篇综述强调了最近与皮肤老化有关的分子发现，并评估了预防方法，如局部使用维甲酸。局部类维生素A已被证明有望增强皮肤纹理，减少细纹，并增加表皮和真皮层的厚度。
The skin is the most-extensive and -abundant tissue in the human body. Like many organs, as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This can be primarily attributed to the diminishing population of epidermal stem cells and the reduction in collagen, which is the primary structural protein in the human body. The alterations occurring in the epidermis and dermis due to the aging process result in disruptions to the structure and functionality of the skin. This creates a microenvironment conducive to age-related skin conditions such as a compromised skin barrier, slowed wound healing, and the onset of skin cancer. This review emphasizes the recent molecular discoveries related to skin aging and evaluates preventive approaches, such as the use of topical retinoids. Topical retinoids have demonstrated promise in enhancing skin texture, diminishing fine lines, and augmenting the thickness of both the epidermal and dermal layers.
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影响因子：
8.8
作者：
Goodwin JM;Dowdle WE;DeJesus R;Wang Z;Bergman P;Kobylarz M;Lindeman A;Xavier RJ;McAllister G;Nyfeler B;Hoffman G;Murphy LO
通讯作者：
Murphy LO
影响因子：
3.7
作者：
Juric V;Chen CC;Lau LF
通讯作者：
Lau LF
影响因子：
7.8
作者：
BouGharios, G;Garrett, LA;deCrombrugghe, B
通讯作者：
deCrombrugghe, B
影响因子：
6.5
作者：
Dumit, Veronica I.;Kuettner, Victoria;Kaeppler, Jakob;Piera-Velazquez, Sonsoles;Jimenez, Sergio A.;Bruckner-Tuderman, Leena;Uitto, Jouni;Dengjel, Joern
通讯作者：
Dengjel, Joern
影响因子：
5.6
作者：
Hegedus, Luca;Cho, Hyojin;Eliceiri, George L.
通讯作者：
Eliceiri, George L.