Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression.
Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression.
复制标题
倒退时间：靶向肿瘤浸润髓样细胞以恢复癌症的进展。
DOI：
10.3389/fimmu.2018.01977
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发表时间：
2018
影响因子：
7.3
通讯作者：
Breckpot K
中科院分区：
文献类型：
--
作者：
Awad RM;De Vlaeminck Y;Maebe J;Goyvaerts C;Breckpot K
肿瘤细胞经常产生可溶性因子，其有利于骨髓生成和骨髓细胞向肿瘤微环境（TME）的募集。因此，许多癌症类型的TME的特征是单核细胞、巨噬细胞、树突状细胞和粒细胞的高度浸润。实验和临床研究表明，大多数骨髓细胞在TME中保持不成熟状态。这些研究进一步表明，肿瘤衍生因子将这些骨髓细胞塑造成支持癌症起始和进展的细胞，其中包括通过使免疫逃避、肿瘤细胞存活、增殖、迁移和转移成为可能。骨髓细胞在癌症中的关键作用进一步证明了它们对几乎所有类型的癌症治疗产生负面影响的事实。因此，肿瘤相关的骨髓细胞已被指定为癌症的罪魁祸首。我们回顾了骨髓细胞在TME的重点是他们利用支持癌细胞的机制。此外，我们还概述了正在研究中的耗尽骨髓细胞或重定向其功能的方法，因为这些方法有望克服对当前癌症治疗的耐药性。
Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages, dendritic cells and granulocytes. Experimental and clinical studies show that most myeloid cells are kept in an immature state in the TME. These studies further show that tumor-derived factors mold these myeloid cells into cells that support cancer initiation and progression, amongst others by enabling immune evasion, tumor cell survival, proliferation, migration and metastasis. The key role of myeloid cells in cancer is further evidenced by the fact that they negatively impact on virtually all types of cancer therapy. Therefore, tumor-associated myeloid cells have been designated as the culprits in cancer. We review myeloid cells in the TME with a focus on the mechanisms they exploit to support cancer cells. In addition, we provide an overview of approaches that are under investigation to deplete myeloid cells or redirect their function, as these hold promise to overcome resistance to current cancer therapies.
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DOI：
10.1084/jem.20120690
发表时间：
2013-11-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Avraham-Davidi I;Yona S;Grunewald M;Landsman L;Cochain C;Silvestre JS;Mizrahi H;Faroja M;Strauss-Ayali D;Mack M;Jung S;Keshet E
通讯作者：
Keshet E
影响因子：
7.3
作者：
Albini A;Bruno A;Noonan DM;Mortara L
通讯作者：
Mortara L
DOI：
10.1016/j.biocel.2007.04.021
发表时间：
2007-01-01
影响因子：
4
作者：
Biswas, Subhra K.;Tergaonkarl, Vinay
通讯作者：
Tergaonkarl, Vinay
影响因子：
8.8
作者：
Aras S;Zaidi MR
通讯作者：
Zaidi MR
影响因子：
4.4
作者：
Breckpot, Karine;Aerts-Toegaert, Cindy;Thielemans, Kris
通讯作者：
Thielemans, Kris