Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering.
Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering.
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DOI：
10.1016/j.biomaterials.2010.02.044
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发表时间：
2010-06
期刊：
影响因子：
14
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Zhu J
在这篇综述中，我们探索了将生物活性引入聚乙二醇水凝胶的不同方法。水凝胶是修复和再生各种组织的优秀支架材料，因为它们可以提供类似于软组织的高度膨胀的三维(3D)环境。与天然水凝胶相比，合成水凝胶如聚乙二醇基水凝胶具有更好的性能，如光聚合能力、机械性能可调、支架结构和化学成分易于控制等。然而，由于其生物惰性，单靠聚乙二醇水凝胶不能提供理想的环境来支持细胞黏附和组织形成。天然细胞外基质(ECM)是组织工程生物活性支架设计和制备的理想材料。模拟ECM修饰的聚乙二醇水凝胶已成为调节特定细胞反应的重要策略。为了将细胞外基质衍生的生物活性分子(BMS)连接到聚乙二醇水凝胶上，人们已经开发了各种策略来整合ECM的关键生物功能，如特定的细胞黏附、蛋白降解和信号分子结合。许多细胞类型已经被固定在生物活性的聚乙二醇水凝胶上，以提供细胞/支架相互作用的基础知识。本文综述了生物活性水凝胶作为组织工程支架材料设计和制备方法的最新进展。
In this review, we explore different approaches for introducing bioactivity into poly(ethylene glycol) (PEG) hydrogels. Hydrogels are excellent scaffolding materials for repairing and regenerating a variety of tissues because they can provide a highly swollen three-dimensional (3D) environment similar to soft tissues. Synthetic hydrogels like PEG-based hydrogels have advantages over natural hydrogels, such as the ability for photopolymerization, adjustable mechanical properties, and easy control of scaffold architecture and chemical compositions. However, PEG hydrogels alone cannot provide an ideal environment to support cell adhesion and tissue formation due to their bio-inert nature. The natural extracellular matrix (ECM) has been an attractive model for the design and fabrication of bioactive scaffolds for tissue engineering. ECM-mimetic modification of PEG hydrogels has emerged as an important strategy to modulate specific cellular responses. To tether ECM-derived bioactive molecules (BMs) to PEG hydrogels, various strategies have been developed for the incorporation of key ECM biofunctions, such as specific cell adhesion, proteolytic degradation, and signal molecule-binding. A number of cell types have been immobilized on bioactive PEG hydrogels to provide fundamental knowledge of cell/scaffold interactions. This review addresses the recent progress in material designs and fabrication approaches leading to the development of bioactive hydrogels as tissue engineering scaffolds.
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影响因子：
6.1
作者：
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通讯作者：
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