Stem cell treatment for the spinal cord injury – A concise review
Stem cell treatment for the spinal cord injury – A concise review
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脊髓损伤的干细胞治疗——简述
DOI：
10.1016/j.ijnt.2014.05.008
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发表时间：
2014
影响因子：
0.2
通讯作者：
Y. Dewan
中科院分区：
文献类型：
--
作者：
Venkatesh Ponemone;K. Choudhury;K. Harris;Y. Dewan
脊髓损伤（SCI）是由于外伤引起的脊髓损伤，主要包括与脊髓相关的神经损伤，可分为完全性损伤和不完全性损伤。由于事故和外伤导致的下半身残疾中，脊髓损伤占大多数。细胞移植作为脊髓损伤（SCI）的一种治疗干预手段，近年来被科学家和研究人员广泛研究，干细胞在治疗SCI患者中显示出相当大的前景，从而通过替换丢失或受损的细胞群来恢复失去的功能。由于事故和外伤导致的下半身残疾中，脊髓损伤占大多数。脊髓损伤也为许多其他与血管和骨骼畸形相关的残疾铺平了道路。从经济上讲，脊髓损伤的全球负担高达数百万人，因为完全治愈是不可能的。为脊髓损伤的第一阶段研究进行的临床试验数量惊人，目前有246项试验处于初始阶段。然而，许多问题仍未得到解答，更多的问题仍在继续出现。本综述将全面涵盖近年来该领域的出版物，并考察SCI的生物学效应。
A spinal cord injury (SCI) is any injury of the spinal cord caused due to trauma and mostly comprise of damage to the nerves associated with the spinal cord and they can be classified as being complete or incomplete. Spinal cord injuries account for a majority of lower body disabilities due to accidents and trauma. Cell transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been extensively studied by scientists and researchers in recent years using stem cell that has shown considerable promise in treating patients with SCI and thus restores lost functions by replacing lost or damaged cell populations. Spinal cord injuries account for a majority of lower body disabilities due to accidents and trauma. SCI also paves way for a lot of other disabilities associated with blood vessels as well and bone deformities. The global burden of SCI, economically, runs into millions as complete cure is not possible. The number of clinical trials that have been conducted for phase 1 studies of spinal cord injury is a staggering number and currently 246 trials are being conducted in their initial phases. However, many questions remain unanswered and more continue to emerge. This review will comprehensively cover publications in the field from the last years and examine the biological effects of SCI.
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影响因子：
3.4
作者：
Ikegami, T;Nakamura, M;Okano, H
通讯作者：
Okano, H
影响因子：
3.7
作者：
Kumagai G;Okada Y;Yamane J;Nagoshi N;Kitamura K;Mukaino M;Tsuji O;Fujiyoshi K;Katoh H;Okada S;Shibata S;Matsuzaki Y;Toh S;Toyama Y;Nakamura M;Okano H
通讯作者：
Okano H
影响因子：
4.2
作者：
Wu, SF;Suzuki, Y;Ide, C
通讯作者：
Ide, C
影响因子：
5.2
作者：
Yoon, Seung Hwan;Shim, Yu Shik;Ha, Yoon
通讯作者：
Ha, Yoon
影响因子：
3
作者：
Samdani, Amer F.;Paul, Courtney;Neuhuber, Birgit
通讯作者：
Neuhuber, Birgit