Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing.
Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing.
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植入前基因检测中染色体易位性别对囊胚形成及妊娠结局的影响。
DOI：
10.3389/fendo.2021.704299
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发表时间：
2021
影响因子：
5.2
通讯作者：
Zhang YL
中科院分区：
文献类型：
--
作者：
Song H;Shi H;Yang ET;Bu ZQ;Jin ZQ;Huo MZ;Zhang YL
目的探讨胚胎着床前基因检测中染色体易位性别对囊胚形成及妊娠结局的影响，包括不同亲代年龄。本研究是一项回顾性队列研究，纳入2015年1月至2019年12月在郑州大学第一附属医院生殖医学中心进行胚胎植入前基因检测-因染色体易位携带者进行结构重排的1034对夫妇。A组有528对夫妇，其中男性是反向易位的携带者；B组有506对夫妇，其中女性是反向易位的携带者。所有患者根据年龄分为两组：女性年龄<35岁和女性年龄≥35岁。此外，根据父亲的年龄，进一步探讨各组男女携带者囊胚状况和妊娠结局的差异。A组囊胚成形率（55.3%）高于B组（50%），差异有统计学意义（P<0.05）。无论是年轻产妇年龄还是高龄产妇，A组囊胚形成率均高于B组（P<0.05）。A组母鼠年龄<35岁、父鼠年龄<30岁的囊胚形成率（57.1%）高于B组（50%）；同样，母亲年龄≥35岁和父亲年龄≥38岁组的囊胚形成率（66.7%）高于B组（33.3%）（均P<0.05）。A组与b组受精率、非整倍体率、临床妊娠率、流产率、活产率均无差异。当反向易位的携带者为男性时，囊胚形成率高于女性携带者。而两者在受精率、非整倍体率、临床妊娠率、流产率和活产率方面无显著差异。
To determine the effect of gender of reciprocal chromosomal translocation on blastocyst formation and pregnancy outcome in preimplantation genetic testing, including different parental ages. This was a retrospective cohort study that enrolled 1034 couples undergoing preimplantation genetic testing-structural rearrangement on account of a carrier of reciprocal chromosomal translocation from the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2015 to December 2019. Group A represented 528 couples in which the man was the carrier of reciprocal translocation and group B represented 506 couples in which the woman was the carrier of reciprocal translocation. All patients were divided into two groups according to their age: female age<35 and female age≥35. Furthermore, the differences in blastocyst condition and pregnancy outcome between male and female carriers in each group were further explored according to their father’s age. The blastocyst formation rate of group A (55.3%) is higher than that of group B (50%) and the results were statistically significant (P<0.05). The blastocyst formation rate of group A is higher than that of group B, no matter in young maternal age or in advanced maternal age (P<0.05). The blastocyst formation rate in maternal age<35y and paternal age<30y in group A(57.1%) is higher than that of Group B(50%); Similarly, the blastocyst formation rate in maternal age≥35 and paternal age≥38y(66.7%) is higher than that of Group B(33.3%)(all P<0.05). There was no difference in fertilization rate, aeuploidy rate, clinical pregnancy rate, miscarriage rate and live birth rate between Group A and Group B. When the carrier of reciprocal translocation is male, the blastocyst formation rate is higher than that of female carrier. While there is no significant difference between the two in terms of fertilization rate, aeuploidy rate, clinical pregnancy rate, miscarriage rate and live birth rate.
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影响因子：
4
作者：
Ye, Yinghui;Qian, Yuli;Jin, Fan
通讯作者：
Jin, Fan
在易位病例中使用单核苷酸多态性微阵列进行植入前遗传学诊断后，活检的囊胚数量作为获得至少一个正常/平衡胚胎的预测指标
影响因子：
3.1
作者：
Wang YZ;Ding CH;Wang J;Zeng YH;Zhou W;Li R;Zhou CQ;Deng MF;Xu YW
通讯作者：
Xu YW
影响因子：
6.7
作者：
Simon, Alexander L.;Kiehl, Michelle;Demko, Zachary P.
通讯作者：
Demko, Zachary P.
影响因子：
6.7
作者：
Hodes-Wertz, Brooke;Grifo, Jamie;Munne, Santiago
通讯作者：
Munne, Santiago
影响因子：
3.1
作者：
Kort, Jonathan D.;McCoy, Rajiv C.;Lathi, Ruth B.
通讯作者：
Lathi, Ruth B.