Comparison of glycoprotein expression between ovarian and colon adenocarcinomas.
Comparison of glycoprotein expression between ovarian and colon adenocarcinomas.
复制标题
卵巢腺癌和结肠腺癌之间糖蛋白表达的比较。
DOI：
--
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发表时间：
1999
影响因子：
4.6
通讯作者：
M. Warhol
中科院分区：
文献类型：
--
作者：
H. Multhaupt;C. Arenas;M. Warhol
目的
肿瘤相关抗原可以表达为表面糖蛋白。这些分子在细胞分化和恶性转化过程中经历定性和定量修饰。在恶性转化期间，不完全糖基化是常见的，并且某些糖基化途径是优选的。这些抗原可能有助于区分卵巢和结肠腺癌的原发灶和转移灶。不同的细胞角蛋白已被提出作为相对器官特异性抗原。
设计
我们使用抗T1、Tn、唾液酸Tn、B72.3、CA 125、癌胚抗原和细胞角蛋白7和20的单克隆抗体检测卵巢癌和结肠癌中的肿瘤相关糖蛋白和角蛋白。
结果
CA 125、癌胚抗原和细胞角蛋白7和20可以区分原发性和转移性病变中的结肠癌和卵巢浆液性或类浆液性腺癌。粘液性卵巢腺癌的不同之处在于它们表达癌胚抗原和细胞角蛋白7和20，弱表达CA 125。其他糖蛋白抗原在卵巢癌和结肠腺癌中表达相同，因此在区分这两种实体中没有用处。
结论
一组抗细胞角蛋白7和20抗原、CA 125和癌胚抗原的单克隆抗体可用于鉴别卵巢浆液性和类浆液性腺癌与结肠腺癌。粘液性卵巢腺癌不能用免疫组化与结肠腺癌区分。
OBJECTIVE
Tumor-associated antigens may be expressed as surface glycoproteins. These molecules undergo qualitative and quantitative modifications during cell differentiation and malignant transformation. During malignant transformation, incomplete glycosylation is common, and certain glycosylation pathways are preferred. These antigens might help distinguish between ovarian and colonic adenocarcinomas in the primary and metastatic lesions. Different cytokeratins have been proposed as relatively organ-specific antigens.
DESIGN
We used monoclonal antibodies against T1, Tn, sialosyl-Tn, B72.3, CA125, carcinoembryonic antigen, and cytokeratins 7 and 20 to detect tumor-associated glycoproteins and keratin proteins in ovarian and colonic carcinomas.
RESULTS
CA125, carcinoembryonic antigen, and cytokeratins 7 and 20 can distinguish between colonic and serous or endometrioid adenocarcinomas of the ovary in both primary and metastatic lesions. Mucinous ovarian adenocarcinomas differed in that they express carcinoembryonic antigen and cytokeratins 7 and 20 and weakly express CA125. The other glycoprotein antigens were equally expressed by ovarian and colonic adenocarcinomas and therefore were of no use in distinguishing between these 2 entities.
CONCLUSION
A panel of monoclonal antibodies against cytokeratins 7 and 20 antigens, CA125, and carcinoembryonic antigen is useful in differentiating serous and endometrioid adenocarcinomas of the ovary from colonic adenocarcinomas. Mucinous ovarian adenocarcinomas cannot be distinguished from colonic adenocarcinomas using immunohistochemistry.
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影响因子：
15.9
作者：
BAST, RC;FEENEY, M;KNAPP, RC
通讯作者：
KNAPP, RC
影响因子：
11.2
作者：
S. Itzkowitz;M. Yuan;C. Montgomery;T. Kjeldsen;H. Takahashi;W. Bigbee;Y. Kim
通讯作者：
S. Itzkowitz;M. Yuan;C. Montgomery;T. Kjeldsen;H. Takahashi;W. Bigbee;Y. Kim
单克隆抗体（B72.3）定义的胸膜恶性间皮瘤和肺腺癌之间的诊断区别。
DOI：
--
发表时间：
1986
期刊：
The American journal of pathology
影响因子：
--
作者：
Szpak,CA;Johnston,WW;Roggli,V;Kolbeck,J;Lottich,SC;Vollmer,R;Thor,A;Schlom,J
通讯作者：
Schlom,J
影响因子：
--
作者：
S. Hakomori
通讯作者：
S. Hakomori
影响因子：
56.9
作者：
SPRINGER, GF
通讯作者：
SPRINGER, GF