Assessment of phalangeal bone loss in patients with rheumatoid arthritis by quantitative ultrasound
Assessment of phalangeal bone loss in patients with rheumatoid arthritis by quantitative ultrasound
复制标题
定量超声评估类风湿性关节炎患者指骨骨丢失情况
DOI：
10.1136/ard.60.7.670
复制
发表时间：
2001
影响因子：
27.4
通讯作者：
C. Glüer
中科院分区：
文献类型：
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作者：
P. Röben;R. Barkmann;S. Ullrich;A. Gause;M. Heller;C. Glüer
目的关节周围骨质减少是类风湿关节炎（RA）的早期影像学表现。定量超声（QUS）设备最近已被证明是有用的评估骨质疏松症。在这项研究中，一个便携式和易于使用的QUS设备的能力，以检测骨骼损伤的手指指骨类风湿关节炎患者进行了调查。方法采用横断面研究方法，对83例女性（对照组30例，糖皮质激素（GC）治疗RA组29例，GC治疗血管炎组24例）进行了检查。使用DBM Sonic 1200（IGEA，意大利）QUS器械，在近端趾骨II-V的干骺端和直接在近端指间关节II-IV处获得QUS测量值。评价了振幅相关声速（AD-SoS）。在23例RA患者中，对手部X线片进行了评价。结果RA患者的AD-SoS在两个测量部位均与其他组有显著性差异。与年龄匹配的对照组相比，RA患者的AD-SoS在干骺端和关节处分别降低了2和3个标准差。无糜烂的RA患者（Larsen评分0-I）的手指QUS值已经显著降低，随着糜烂的发展进一步恶化（Larsen II-V）。结论QUS对类风湿性关节炎关节周围骨丢失敏感。QUS是一种快速、简单、廉价的无电离辐射的方法，似乎适合于检测关节周围骨丢失的早期阶段。其在早期RA评估中的临床应用应在前瞻性研究中进一步评估。
OBJECTIVE Periarticular osteopenia is an early radiological sign of rheumatoid arthritis (RA). Quantitative ultrasound (QUS) devices have recently been shown to be useful for assessing osteoporosis. In this study the capability of a transportable and easy to use QUS device to detect skeletal impairment of the finger phalanges in patients with RA was investigated. METHODS In a cross sectional study 83 women (30 controls, 29 with glucocorticosteroid (GC) treated RA, and 24 with GC treated vasculitis) were examined. QUS measurements were obtained at the metaphyses of the proximal phalanges II–V and directly at the proximal interphalangeal joints II–IV with a DBM Sonic 1200 (IGEA, Italy) QUS device. Amplitude dependent speed of sound (AD-SoS) was evaluated. In 23 of the patients with RA, hand radiographs were evaluated. RESULTS Significant differences between patients with RA and the other groups were found for AD-SoS at both measurement sites. Compared with age matched controls, the AD-SoS of patients with RA was lowered by two and three standard deviations at the metaphysis and joint, respectively. Fingers of patients with RA without erosions (Larsen score 0–I) already had significantly decreased QUS values, which deteriorated further with the development of erosions (Larsen II–V). CONCLUSION This study indicates that QUS is sensitive to phalangeal periarticular bone loss in RA. QUS is a quick, simple, and inexpensive method free of ionising radiation that appears to be suited to detection of early stages of periarticular bone loss. Its clinical use in the assessment of early RA should be further evaluated in prospective studies.
影响因子：
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作者：
D. Bauer;C. Glüer;J. Cauley;T. Vogt;K. Ensrud;H. Genant;D. Black
通讯作者：
D. Bauer;C. Glüer;J. Cauley;T. Vogt;K. Ensrud;H. Genant;D. Black
影响因子：
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作者：
SHARP, JT;WOLFE, F;BLOCH, DA
通讯作者：
BLOCH, DA
类风湿性关节炎患者手部 X 光片的 3 种定量测量的比较：Steinbrocker 分期、Kaye 改良 Sharp 评分和 Larsen 评分。
DOI：
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发表时间：
1997
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Pincus,T;Larsen,A;Brooks,RH;Kaye,J;Nance,EP;Callahan,LF
通讯作者：
Callahan,LF