The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease.
The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease.
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人类微生物组综合项目：在人类健康和疾病期间，微生物组主宿主体剖面的动态分析。
DOI：
10.1016/j.chom.2014.08.014
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发表时间：
2014-09-10
影响因子：
30.3
通讯作者：
Integrative HMP (iHMP) Research Network Consortium
中科院分区：
文献类型：
--
作者：
Integrative HMP (iHMP) Research Network Consortium
关于人类相关微生物群落的多样性和分布，我们已经了解了很多，但我们仍然对微生物组的生物学，它如何与宿主相互作用以及宿主如何对其居民微生物群做出反应知之甚少。综合人类微生物组项目（iHMP，http://hmp2.org）是NIH人类微生物组项目的第二阶段，将通过分析疾病特异性队列纵向研究中的微生物组和宿主活动以及创建微生物组和宿主功能特性的综合数据集来研究这些相互作用。这些数据集将作为实验测试平台，以评估新的模型，方法和对宿主和微生物组相互作用的分析。在这里，我们描述了微生物组相关的人类条件的三种模型，早产，炎症性肠病和2型糖尿病的动态，以及它们的基本假设，以及通过公共存储库收集，整合和分发的多组学数据类型作为社区资源。
Much has been learned about the diversity and distribution of human-associated microbial communities, but we still know little about the biology of the microbiome, how it interacts with the host, and how the host responds to its resident microbiota. The Integrative Human Microbiome Project (iHMP, http://hmp2.org), the second phase of the NIH Human Microbiome Project, will study these interactions by analyzing microbiome and host activities in longitudinal studies of disease-specific cohorts and by creating integrated data sets of microbiome and host functional properties. These data sets will serve as experimental test beds to evaluate new models, methods, and analyses on the interactions of host and microbiome. Here we describe the three models of microbiome-associated human conditions, on the dynamics of preterm birth, inflammatory bowel disease, and type 2 diabetes, and their underlying hypotheses, as well as the multi-omic data types to be collected, integrated, and distributed through public repositories as a community resource.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
9.8
作者：
Ananthakrishnan, Ashwin N.;Huang, Hailiang;Nguyen, Deanna D.;Sauk, Jenny;Yajnik, Vijay;Xavier, Ramnik J.
通讯作者：
Xavier, Ramnik J.
影响因子：
4.4
作者：
Fettweis JM;Serrano MG;Sheth NU;Mayer CM;Glascock AL;Brooks JP;Jefferson KK;Vaginal Microbiome Consortium (additional members);Buck GA
通讯作者：
Buck GA
影响因子：
3.7
作者：
Aagaard K;Riehle K;Ma J;Segata N;Mistretta TA;Coarfa C;Raza S;Rosenbaum S;Van den Veyver I;Milosavljevic A;Gevers D;Huttenhower C;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
3.7
作者：
Erickson AR;Cantarel BL;Lamendella R;Darzi Y;Mongodin EF;Pan C;Shah M;Halfvarson J;Tysk C;Henrissat B;Raes J;Verberkmoes NC;Fraser CM;Hettich RL;Jansson JK
通讯作者：
Jansson JK