Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging.
Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging.
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DOI：
10.1016/j.gie.2008.05.014
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发表时间：
2008-10
影响因子：
7.7
通讯作者：
Tearney, Guillermo J.
中科院分区：
文献类型：
--
作者：
Suter, Melissa J.;Vakoc, Benjamin J.;Yachimski, Patrick S.;Shishkov, Milen;Lauwers, Gregory Y.;Mino-Kenudson, Mari;Bouma, Brett E.;Nishioka, Norman S.;Tearney, Guillermo J.
光学相干断层扫描（OCT）是一种横截面高分辨率成像方式，已被证明可以准确区分食管特化肠上皮化生（SIM）与鳞状柱状交界处（SCJ）的贲门，并诊断SIM患者的高度异型增生和粘膜内癌。然而，OCT的临床实用性受到限制，因为它不能在大面积上采集图像。本研究的目的是使用最近开发的高速OCT技术，称为光学频域成像（OFDI）和一种新的球囊中心导管（直径2.5 cm），以证明患者整个远端食管（~6.0 cm）的大面积全面光学显微镜检查的可行性。试点可行性研究。马萨诸塞州综合医院。12名患者接受常规EGD。10名患者使用OFDI系统和球囊导管成功地进行了食管远端的全面显微镜检查。成像程序未导致并发症。在不到2分钟的时间内获得了体积数据集。SCJ的对外直接投资图像显示了与组织病理学结果一致的各种显微特征，包括鳞状粘膜、贲门、有或无异型增生的SIM和食管糜烂。无法获得对外直接投资数据与组织病理学诊断之间的直接联系。利用对外直接投资和球囊中心导管成功地对人体远端食管进行了全面的容积显微镜检查，提供了大量关于食管壁结构的详细信息。这一技术将为今后比较对外直接投资图像信息与组织病理学诊断的研究提供支持。
Optical coherence tomography (OCT) is a cross-sectional, high-resolution imaging modality that has been shown to accurately differentiate esophageal specialized intestinal metaplasia (SIM) from gastric cardia at the squamocolumnar junction (SCJ) and diagnose high-grade dysplasia and intramucosal carcinoma in patients with SIM. The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas. The aim of this study was to use recently developed high-speed OCT technology, termed optical frequency domain imaging (OFDI), and a new balloon-centering catheter (2.5 cm diameter) to demonstrate the feasibility of large area, comprehensive optical microscopy of the entire distal esophagus (~6.0 cm) in patients. A pilot feasibility study. Massachusetts General Hospital. Twelve patients undergoing routine EGD. Comprehensive microscopy of the distal esophagus was successfully performed in 10 patients with the OFDI system and balloon catheter. There were no complications resulting from the imaging procedure. Volumetric data sets were acquired in less than 2 minutes. OFDI images at the SCJ showed a variety of microscopic features that were consistent with histopathologic findings, including squamous mucosa, cardia, SIM with and without dysplasia, and esophageal erosion. Inability to obtain direct correlation of OFDI data and histopathologic diagnoses. Comprehensive volumetric microscopy of the human distal esophagus was successfully demonstrated with OFDI and a balloon-centering catheter, providing a wealth of detailed information about the structure of the esophageal wall. This technique will support future studies to compare OFDI image information with histopathologic diagnoses.
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影响因子：
3.3
作者：
Montgomery, E;Bronner, MP;Washington, K
通讯作者：
Washington, K
影响因子：
29.4
作者：
Falk, GW;Chittajallu, R;Richter, JE
通讯作者：
Richter, JE
影响因子：
7.7
作者：
Isenberg, G;Sivak, MV;Rollins, A
通讯作者：
Rollins, A
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作者：
Oh, WY;Yun, SH;Bouma, BE
通讯作者：
Bouma, BE
影响因子：
7.7
作者：
Vakoc, Benjamin J.;Shishko, Milen;Bouma, Brett E.
通讯作者：
Bouma, Brett E.