The Central Role of Cytochrome P450 in Xenobiotic Metabolism-A Brief Review on a Fascinating Enzyme Family.
The Central Role of Cytochrome P450 in Xenobiotic Metabolism-A Brief Review on a Fascinating Enzyme Family.
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DOI：
10.3390/jox11030007
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发表时间：
2021-06-22
影响因子：
6
通讯作者：
Kranendonk M
中科院分区：
文献类型：
--
作者：
Esteves F;Rueff J;Kranendonk M
人细胞色素P450（CYP 450）酶构成膜结合血红素蛋白的超家族，其负责多种临床、生理和毒理学重要化合物的代谢。这些血红素-硫醇单加氧酶在异生物质的解毒中起着关键作用，参与许多结构不同的化合物的代谢。本文简要综述了CYP在I期异生物质代谢中的主要作用。该手稿集中在八个主要主题上，包括过去和现在的研究中最相关的方面。首先，（I）概述了外源性物质的吸收、分布、代谢和排泄（ADME）的主要方面。其次是（二）背景综述，介绍了该领域过去的主要成就。(III)简要综述了CYP的分类和命名，并对CYP在哺乳动物体内的定位和功能进行了概述。随后，（V）的生理相关性，作为第一阶段异生物质代谢的基石突出，其次是（VI）审查两个遗传决定因素和（VI）非遗传因素的功能和活动。审查的最后一个主题（八）是集中在当前的挑战，生物多样性研究领域。
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound hemoproteins that are responsible for the metabolism of a wide variety of clinically, physiologically, and toxicologically important compounds. These heme-thiolate monooxygenases play a pivotal role in the detoxification of xenobiotics, participating in the metabolism of many structurally diverge compounds. This short-review is intended to provide a summary on the major roles of CYPs in Phase I xenobiotic metabolism. The manuscript is focused on eight main topics that include the most relevant aspects of past and current CYP research. Initially, (I) a general overview of the main aspects of absorption, distribution, metabolism, and excretion (ADME) of xenobiotics are presented. This is followed by (II) a background overview on major achievements in the past of the CYP research field. (III) Classification and nomenclature of CYPs is briefly reviewed, followed by (IV) a summary description on CYP’s location and function in mammals. Subsequently, (V) the physiological relevance of CYP as the cornerstone of Phase I xenobiotic metabolism is highlighted, followed by (VI) reviewing both genetic determinants and (VI) nongenetic factors in CYP function and activity. The last topic of the review (VIII) is focused on the current challenges of the CYP research field.
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影响因子：
2.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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