AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.
AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.
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AcidoCEST-UTE MRI 显示膝骨关节炎的酸性微环境。
DOI：
10.3390/ijms23084466
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发表时间：
2022-04-18
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
先前已经证明了关节中的酸性pH、骨关节炎（OA）和疼痛之间的关系。酸中毒化学交换饱和转移（acidoCEST）通过评估碘化造影剂上的酰胺基团与大量水之间的质子交换，间接测量细胞外pH值。使用acidoCEST MRI可以估计骨关节炎关节的细胞外pH值。然而，传统的MR序列不能对软骨、半月板、韧带和其他肌肉骨骼组织的深层进行成像，这些组织具有短回波时间和快速信号衰减。另一方面，超短回波时间（UTE）MRI已成功用于对这些关节组织进行成像。在此，我们的目标是比较使用acidoCEST-UTE MRI测量的无OA志愿者和重度OA患者膝关节的pH值。使用acidoCEST-UTE MRI检查无膝关节OA的患者和重度OA患者，并计算软骨、半月板和液体的平均pH值。此外，还研究了pH测量值与膝关节损伤和骨关节炎结局评分（KOOS）之间的关系。AcidoCEST-UTE MRI可以检测膝关节软骨、半月板和关节液的pH值在无OA和有OA关节之间的显著差异，OA显示较低的pH值。此外，症状和膝关节功能在较低的pH测量值下变得更糟。
A relationship between an acidic pH in the joints, osteoarthritis (OA), and pain has been previously demonstrated. Acidosis Chemical Exchange Saturation Transfer (acidoCEST) indirectly measures the extracellular pH through the assessment of the exchange of protons between amide groups on iodinated contrast agents and bulk water. It is possible to estimate the extracellular pH in the osteoarthritic joint using acidoCEST MRI. However, conventional MR sequences cannot image deep layers of cartilage, meniscus, ligaments, and other musculoskeletal tissues that present with short echo time and fast signal decay. Ultrashort echo time (UTE) MRI, on the other hand, has been used successfully to image those joint tissues. Here, our goal is to compare the pH measured in the knee joints of volunteers without OA and patients with severe OA using acidoCEST-UTE MRI. Patients without knee OA and patients with severe OA were examined using acidoCEST-UTE MRI and the mean pH of cartilage, meniscus, and fluid was calculated. Additionally, the relationship between the pH measurements and the Knee Injury and Osteoarthritis Outcome Score (KOOS) was investigated. AcidoCEST-UTE MRI can detect significant differences in the pH of knee cartilage, meniscus, and fluid between joints without and with OA, with OA showing lower pH values. In addition, symptoms and knee-joint function become worse at lower pH measurements.
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影响因子：
2.9
作者：
Lombardi AF;Jang H;Wei Z;Jerban S;Wallace M;Masuda K;Ma YJ
通讯作者：
Ma YJ
影响因子：
3.1
作者：
Lombardi AF;Wong JH;High R;Ma Y;Jerban S;Tang Q;Du J;Frost P;Pagel MD;Chang EY
通讯作者：
Chang EY
影响因子：
11.4
作者：
Deval, Emmanuel;Noel, Jacques;Lingueglia, Eric
通讯作者：
Lingueglia, Eric
影响因子：
2.8
作者：
High, Rachel A.;Ji, Yang;Chang, Eric Y.
通讯作者：
Chang, Eric Y.
影响因子：
4.4
作者：
Chang, Eric Y.;Du, Jiang;Chung, Christine B.
通讯作者：
Chung, Christine B.