High-contrast osteochondral junction imaging using a 3D dual adiabatic inversion recovery-prepared ultrashort echo time cones sequence.
High-contrast osteochondral junction imaging using a 3D dual adiabatic inversion recovery-prepared ultrashort echo time cones sequence.
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DOI：
10.1002/nbm.4559
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发表时间：
2021-08
影响因子：
2.9
通讯作者：
Ma YJ
中科院分区：
文献类型：
--
作者：
Lombardi AF;Jang H;Wei Z;Jerban S;Wallace M;Masuda K;Ma YJ
传统的MRI序列由于骨软骨交界处（OCJ）组织的T2/T2*横向弛驰较短，因此无法显示这些组织，而超短回波时间（UTE）序列可以克服这一限制。此前已经开发了一种具有双绝热反转恢复制备（DIR-UTE）的2D UTE序列，用于高对比度的短T2组织的选择性成像，但对涡流的高灵敏度和混叠的片外激发使得很难在体内成像OCJ的薄层。在这里，我们将DIR方案与3D UTE cone序列相结合，用于体内OCJ组织的体积成像，目的是与最近开发的具有脂肪饱和模块的单一ir制备的UTE序列（IR-FS-UTE）相比，产生更高的OCJ对比度。所有序列均在3T临床扫描仪上进行。DIR-UTE锥体序列将一个三维UTE锥体序列与两个分别以水和脂肪为中心的窄带绝热红外制备脉冲相结合。3D DIR-UTE锥体序列首先应用于一个假体，然后应用于四名健康志愿者和四名诊断为骨关节炎的患者的膝盖，并与IR-FS-UTE序列进行比较。在幻影和志愿者研究中，所提出的DIR-UTE锥体序列比IR-FS-UTE序列显示出更高的OCJ成像对比度。3D DIR-UTE锥体序列显示OCJ与软骨下骨脂肪（BF）（平均值，标准差（SD）： 25.7±2.3）和OCJ与软骨浅层（SC）（平均值，SD: 22.2±3.5）之间的对比噪声比（CNR）显著高于IR-FS-UTE序列（平均值，SD分别为10.8±2.5和16.3±2.6）。三维DIR-UTE cone序列可用于膝关节OCJ区域的活体成像，具有高分辨率和高对比度。DIR-UTE锥体序列将3D UTE锥体序列与两个以水和脂肪频谱频率为中心的窄带绝热红外准备脉冲相结合，应用于4名健康志愿者和4名骨关节炎患者的假体，并与IR- fs -UTE序列进行比较。所提出的DIR-UTE锥体序列在假体和活体膝关节研究中显示骨软骨连接处和骨髓脂肪之间以及骨软骨连接处和浅表软骨之间具有较高的对比噪声比。
While conventional MRI sequences cannot visualize tissues from the osteochondral junction (OCJ) due to these tissues’ short transverse T2/T2* relaxations, ultrashort echo time (UTE) sequences can overcome this limitation. A 2D UTE sequence with a dual adiabatic inversion recovery preparation (DIR-UTE) for selective imaging of short T2 tissues with high contrast has previously been developed, but high sensitivity to eddy currents and aliased out-of-slice excitation make it difficult to image the thin layer of the OCJ in vivo. Here, we combine the DIR scheme with a 3D UTE Cones sequence for volumetric imaging of OCJ tissues in vivo, aiming to generate higher OCJ contrast compared with a recently developed single IR-prepared UTE sequence with a fat saturation module (IR-FS-UTE). All sequences were implemented on a 3T clinical scanner. The DIR-UTE Cones sequence combined a 3D UTE Cones sequence with two narrow-band adiabatic IR preparation pulses centered on water and fat spectrum frequencies, respectively. The 3D DIR-UTE Cones sequence was first applied to a phantom, then to the knees of four healthy volunteers and four patients diagnosed with osteoarthritis and compared to the IR-FS-UTE sequence. In both phantom and volunteer studies, the proposed DIR-UTE Cones sequence showed much higher contrast for OCJ imaging than the IR-FS-UTE sequence did. The 3D DIR-UTE Cones sequence showed a significantly higher contrast-to-noise ratio (CNR) between the OCJ and subchondral bone fat (BF) (mean, standard deviation (SD): 25.7 ± 2.3) and between the OCJ and superficial layers of cartilage (SC) (mean, SD: 22.2 ± 3.5) compared to the IR-FS-UTE sequence (mean, SD: 10.8 ± 2.5 and 16.3 ± 2.6, respectively). The 3D DIR-UTE Cones sequence is feasible for imaging of the OCJ region of the knee in vivo and produces both high resolution and high contrast. A DIR-UTE Cones sequence combining a 3D UTE Cones sequence with two narrow-band adiabatic IR preparation pulses centered on water and fat spectrum frequencies was implemented and applied to a phantom, to the knees of four healthy volunteers and four patients with osteoarthritis and compared to an IR-FS-UTE sequence. The proposed DIR-UTE Cones sequence showed higher contrast-to-noise ratio between osteochondral junction and bone marrow fat and between osteochondral junction and superficial cartilage in both phantom and in vivo knee studies.
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DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
影响因子：
3.3
作者：
Du J;Takahashi AM;Bae WC;Chung CB;Bydder GM
通讯作者：
Bydder GM
影响因子：
--
作者：
Hwang, Jennifer;Bae, Won C.;Shieu, Wendy;Lewis, Chad W.;Bugbee, William D.;Sah, Robert L.
通讯作者：
Sah, Robert L.
影响因子：
5.9
作者：
Kühn JP;Hernando D;Meffert PJ;Reeder S;Hosten N;Laqua R;Steveling A;Ender S;Schröder H;Pillich DT
通讯作者：
Pillich DT
影响因子：
2.6
作者：
Mackay, James W.;Low, Samantha B. L.;Toms, Andoni P.
通讯作者：
Toms, Andoni P.