Influence of Aging, Macronutrient Composition and Time-Restricted Feeding on the Fischer344 x Brown Norway Rat Gut Microbiota.
Influence of Aging, Macronutrient Composition and Time-Restricted Feeding on the Fischer344 x Brown Norway Rat Gut Microbiota.
复制标题
老化、常量营养素组成和限时喂养对Fischer 344 x Brown Norway大鼠肠道微生物群的影响。
作者：
生酮饮食（KD）和限时喂养（TRF）方案都能够影响身体健康的几个参数，包括肠道微生物组组成和循环细胞因子浓度。此外，这两种饮食干预措施都可以预防与衰老过程相关的常见损伤。然而，显著改变KD所需的大量营养素摄入量可能对个体没有吸引力，并降低对饮食治疗的依从性。与KD不同，TRF允许个体继续吃他们习惯的食物，只需要改变他们吃饭的时间。因此，我们在TRF的背景下研究了KD和具有更像西方的大量营养素特征的饮食，并将两种饮食与允许在年轻成年大鼠和老年大鼠中自由进食标准食物的动物进行了比较。虽然观察到对细胞因子水平的有限影响，但微生物组分析（16S测序和宏基因组学）的两种方法均表明TRF和KD显著改变了老年大鼠的肠道微生物组。这些变化在很大程度上取决于单独喂养模式的变化（TRF与随意），而不考虑许多肠道微生物群的大量营养素含量，但也存在大量营养素特异性变化。具体而言，功能分析表明几种途径存在显著差异，包括参与三羧酸（TCA）循环、碳水化合物代谢和神经退行性疾病的途径。这些数据表明，与年龄和疾病相关的肠道生态失调可以通过使用TRF与标准饮食和KD来改善。
Both ketogenic diets (KD) and time-restricted feeding (TRF) regimens have the ability to influence several parameters of physical health, including gut microbiome composition and circulating cytokine concentration. Moreover, both of these dietary interventions prevent common impairments associated with the aging process. However, significantly altering macronutrient intake, which is required for a KD, may be unappealing to individuals and decrease compliance to dietary treatments. In contrast to a KD, TRF allows individuals to continue eating the foods they are used to, and only requires a change in the time of day at which they eat. Therefore, we investigated both a KD and a diet with a more Western-like macronutrient profile in the context of TRF, and compared both diets to animals allowed access to standard chow ad libitum in young adult and aged rats. While limited effects on cytokine levels were observed, both methods of microbiome analysis (16S sequencing and metagenomics) indicate that TRF and KDs significantly altered the gut microbiome in aged rats. These changes were largely dependent on changes to feeding paradigm (TRF vs. ad libitum) alone regardless of macronutrient content for many gut microbiota, but there were also macronutrient-specific changes. Specifically, functional analysis indicates significant differences in several pathways, including those involved in the tricarboxylic acid (TCA) cycle, carbohydrate metabolism and neurodegenerative disease. These data indicate that age- and disease-related gut dysbiosis may be ameliorated through the use of TRF with both standard diets and KDs.
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DOI：
10.1093/gerona/glv189
发表时间：
2016-03-01
影响因子：
5.1
作者：
Gopinath, Bamini;Russell, Joanna;Mitchell, Paul
通讯作者：
Mitchell, Paul
影响因子：
29
作者：
Brandhorst S;Choi IY;Wei M;Cheng CW;Sedrakyan S;Navarrete G;Dubeau L;Yap LP;Park R;Vinciguerra M;Di Biase S;Mirzaei H;Mirisola MG;Childress P;Ji L;Groshen S;Penna F;Odetti P;Perin L;Conti PS;Ikeno Y;Kennedy BK;Cohen P;Morgan TE;Dorff TB;Longo VD
通讯作者：
Longo VD
影响因子：
--
作者：
Arbour, Megan W;Stec, Melissa;Wika, Judith C
通讯作者：
Wika, Judith C
影响因子：
5.2
作者：
Hernandez, Abbi;Truckenbrod, Leah;Burke, Sara
通讯作者：
Burke, Sara
DOI：
10.1152/ajpregu.00072.2020
发表时间：
2021-05-01
影响因子：
2.8
作者：
Kemp, Keri M.;Colson, Jackson;Pollock, Jennifer S.
通讯作者：
Pollock, Jennifer S.