Stronger bone correlates with African admixture in African-American women.
Stronger bone correlates with African admixture in African-American women.
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DOI：
10.1002/jbmr.430
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Seldin MF
中科院分区：
文献类型：
--
作者：
Chen Z;Qi L;Beck TJ;Robbins J;Wu G;Lewis CE;Cauley JA;Wright NC;Seldin MF
骨质疏松症影响所有人群，但低骨密度和骨折的风险因自我报告的种族和民族而差异很大。在这篇文章中，测量百分比非洲混合物和髋关节结构几何形状之间的关系，估计从髋关节结构分析（HSA）计划，在妇女健康倡议（WHI）的一个子队列进行了检查。研究样本包括793名非洲裔美国妇女和8559名非西班牙裔白色妇女。所有参与者在招募时均已绝经，年龄在50至79岁之间，并随访长达9年。采用双能X线骨密度仪评估骨密度和髋关节几何形状。使用遗传祖先信息标记测量非裔美国人的非洲混合物。多元回归和混合效应模型分别用于横断面和纵向分析。从问卷调查和身体测量评估的协变量被纳入分析中，以控制可能的混杂效应。研究结果表明，非洲混合物的百分比和HSA评估之间存在显着相关性。与非西班牙裔白色女性相比，观察到非洲混血女性的骨强度显著更高，如较高的髋部骨矿物质密度和较强的髋部几何形状所示。然而，在随访期间，非洲混血儿比例较高的女性比非西班牙裔白色女性的骨强度降低更大。
Osteoporosis affects all populations, but the risk for low bone density and fracture varies greatly by self-reported race and ethnicity. In this article, the relationship between measured percent African admixture and hip structural geometry, estimated from the hip structural analysis (HSA) program, was examined in a subcohort of the Women’s Health Initiative (WHI). The study sample included 793 African-American women and 8559 non-Hispanic white women. All the participants were postmenopausal, between the ages of 50 and 79 years, at the time of recruitment and were followed for up to 9 years. Bone density and hip geometry were assessed using dual-energy X-ray absorptiometry. African admixture was measured for African Americans using genetic ancestry informative markers. Multiple regression and mixed-effects models were used for cross-sectional and longitudinal analyses, respectively. Covariates assessed from questionnaires and physical measurements were included in the analysis to control for possible confounding effects. The study results show significant correlations between percent of African admixture and HSA assessments. In comparison with non-Hispanic white women, significantly greater bone strength, as indicated by higher hip bone mineral density and stronger hip geometry, in women with higher African admixture was observed. However, women with higher percent African admixture had larger reductions in bone strength than non-Hispanic white women during the follow-up.
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影响因子：
3.9
作者：
Kosoy, Roman;Nassir, Rami;Tian, Chao;White, Phoebe A.;Butler, Lesley M.;Silva, Gabriel;Kittles, Rick;Alarcon-Riquelme, Marta E.;Gregersen, Peter K.;Belmont, John W.;De La Vega, Francisco M.;Seldin, Michael F.
通讯作者：
Seldin, Michael F.
影响因子：
9.8
作者：
Mao, Xianyun;Bigham, Abigail W.;Parra, Esteban J.
通讯作者：
Parra, Esteban J.
DOI：
10.1111/j.1532-5415.2005.53101.x
发表时间：
2005-02-01
影响因子：
6.3
作者：
Cauley, JA;Lui, LY;Ensrud, KE
通讯作者：
Ensrud, KE
影响因子：
6.2
作者：
Cauley, Jane A.;Wu, LieLing;Robbins, John
通讯作者：
Robbins, John
DOI：
10.1080/15412550802363329
发表时间：
2008-10-01
影响因子：
2.2
作者：
Li, Lihua;Brennan, Kathleen J.;Criner, Gerard J.
通讯作者：
Criner, Gerard J.