Revisiting mouse peritoneal macrophages: heterogeneity, development, and function.
Revisiting mouse peritoneal macrophages: heterogeneity, development, and function.
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DOI：
10.3389/fimmu.2015.00225
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发表时间：
2015
影响因子：
7.3
通讯作者：
Bortoluci KR
中科院分区：
文献类型：
--
作者：
Cassado Ados A;D'Império Lima MR;Bortoluci KR
组织巨噬细胞在维持组织稳态中发挥着至关重要的作用，并且还有助于病原体感染和组织损伤期间的炎症和修复反应。这些巨噬细胞的高度异质性与它们对不同组织环境的适应和专门开发利基特异性功能是一致的。尽管腹膜巨噬细胞是研究最充分的巨噬细胞群体之一，但最近证明小鼠腹膜腔 (PerC) 中存在两个亚群共存，这两个亚群表现出不同的表型、功能和起源。这些巨噬细胞亚群根据其形态分为大腹膜巨噬细胞（LPM）和小腹膜巨噬细胞（SPM）。 LPM 是稳态条件下最丰富的子集，表达高水平的 F4/80 和低水平的主要组织相容性复合体 (MHC) II 类分子。 LPM 似乎起源于胚胎发生前体，并且它们在 PerC 中的维持受到特定转录因子和组织衍生信号的表达的调节。相反，SPM 是未刺激 PerC 中的一小部分，具有 F4/80lowMHC-IIhigh 表型，由骨髓来源的骨髓前体细胞产生。为了应对感染或炎症刺激，PerC 的细胞组成发生显着改变，其中 LPM 消失，SPM 与其前体炎症单核细胞一起成为普遍群体。 SPM 似乎是感染期间 PerC 中炎症介质的主要来源，而 LPM 有助于腹膜 B-1 细胞产生肠道相关淋巴组织独立和视黄酸依赖性 IgA。在过去的几年中，我们付出了巨大的努力来扩大我们对 LPM 和 SPM 起源、转录调控和功能谱的理解。本综述讨论了这些问题，重点关注组织源信号和外部刺激对腹膜巨噬细胞群复杂动态的影响。
Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization to develop niche-specific functions. Although peritoneal macrophages are one of the best-studied macrophage populations, recently it was demonstrated the co-existence of two subsets in mouse peritoneal cavity (PerC), which exhibit distinct phenotypes, functions, and origins. These macrophage subsets have been classified, according to their morphology, as large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs). LPMs, the most abundant subset under steady state conditions, express high levels of F4/80 and low levels of class II molecules of the major histocompatibility complex (MHC). LPMs appear to be originated from embryogenic precursors, and their maintenance in PerC is regulated by expression of specific transcription factors and tissue-derived signals. Conversely, SPMs, a minor subset in unstimulated PerC, have a F4/80lowMHC-IIhigh phenotype and are generated from bone-marrow-derived myeloid precursors. In response to infectious or inflammatory stimuli, the cellular composition of PerC is dramatically altered, where LPMs disappear and SPMs become the prevalent population together with their precursor, the inflammatory monocyte. SPMs appear to be the major source of inflammatory mediators in PerC during infection, whereas LPMs contribute for gut-associated lymphoid tissue-independent and retinoic acid-dependent IgA production by peritoneal B-1 cells. In the previous years, considerable efforts have been made to broaden our understanding of LPM and SPM origin, transcriptional regulation, and functional profile. This review addresses these issues, focusing on the impact of tissue-derived signals and external stimulation in the complex dynamics of peritoneal macrophage populations.
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DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
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影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
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DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
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影响因子：
15.9
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