Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.
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DOI：
10.1038/ncomms2877
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
一般范例是单核细胞被募集到炎症部位并最终分化为巨噬细胞。尚未证实生理条件下外周来源的炎症巨噬细胞会增殖。在这里，我们表明，骨髓源性炎症和组织驻留巨噬细胞谱系分支的增殖是炎症过程的关键特征，对炎症恢复的机制具有重大影响。两个巨噬细胞谱系分支在炎症过程中都依赖于 M-CSF，因此治疗干预的潜力是显着的。此外，这些观察结果与 Th2 免疫无关。这些研究表明，不同巨噬细胞群的增殖为炎症期间关键阶段的巨噬细胞扩张提供了一般机制，并且涉及单独的控制机制。
The general paradigm is that monocytes are recruited to sites of inflammation and terminally-differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived inflammatory and tissue resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation. Both macrophage lineage branches are dependent on M-CSF during inflammation, and thus the potential for therapeutic interventions is marked. Furthermore, these observations are independent of Th2 immunity. These studies indicate that the proliferation of distinct macrophage populations provides a general mechanism for macrophage expansion at key stages during inflammation, and separate control mechanisms are implicated.
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Langerhans细胞（LC）增殖介导了新生儿发育，体内平衡和与表皮LC网络的炎症相关扩张。
DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
通讯作者：
Geissmann F
影响因子：
4.4
作者：
Martinez, Fernando O.;Gordon, Siamon;Mantovani, Alberto
通讯作者：
Mantovani, Alberto
影响因子：
6.1
作者：
Isbel, NM;Nikolic-Paterson, DJ;Atkins, RC
通讯作者：
Atkins, RC
DOI：
10.1038/nri3070
发表时间：
2011-10-10
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
32.4
作者：
Serbina, NV;Salazar-Mather, TP;Pamer, EG
通讯作者：
Pamer, EG