Identifying Passerini Products Using a Green, Guided-Inquiry, Collaborative Approach Combined with Spectroscopic Lab Techniques
Identifying Passerini Products Using a Green, Guided-Inquiry, Collaborative Approach Combined with Spectroscopic Lab Techniques
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使用绿色、引导式查询、协作方法结合光谱实验室技术来识别 Passerini 产品
DOI：
10.1021/ed5007184
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发表时间：
2015
影响因子：
3
通讯作者：
Owen P. Priest
中科院分区：
文献类型：
--
作者：
M. Serafin;Owen P. Priest
Passerini多组分反应是其中羧酸、醛和异氰化物反应以形成α-酰氧基酰胺的化学反应。Passerini反应可以在水中而不是传统的有机溶剂如二氯甲烷或MeOH中进行，并且当在水中进行时，该反应的速率加快。为教学实验室设计了一个绿色、引导探究式的合作实验，在水中进行了一系列Passerini反应，同时改变了苯甲酸和苯甲醛上的给电子和吸电子取代基。反应物的各种组合提供了一种有价值的和环保的方式，让学生在本科化学实验室课程，以确定Passerini产品通过各种光谱技术。该实验室被设计成一个引导性的探究，益智实验，学生可以在团队中工作。
The Passerini multicomponent reaction is a chemical reaction in which a carboxylic acid, an aldehyde, and an isocyanide react to form an α-acyloxy amide. The Passerini reaction can be carried out in water instead of traditional organic solvents, such as methylene chloride or MeOH, and the rate of this reaction is accelerated when carried out in water. A green, guided-inquiry, collaborative experiment has been developed for the teaching lab where a series of Passerini reactions have been conducted in water while varying electron donating and withdrawing substituents on benzoic acids and benzaldehydes. The various combinations of reactants offer a valuable and environmentally friendly way to allow students in an undergraduate chemistry lab course to identify Passerini products through various spectroscopic techniques. The lab has been designed to be a guided-inquiry, puzzle experiment that students may work on in teams.
影响因子：
15
作者：
Pirrung, MC;Das Sarma, K
通讯作者：
Das Sarma, K