Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice.
Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice.
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DOI：
10.1002/rmb2.12103
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发表时间：
2018-10
影响因子：
3.4
通讯作者：
Kashiwazaki N
中科院分区：
文献类型：
--
作者：
Namiki T;Ito J;Kashiwazaki N
人类不孕不育已经成为一个严重的社会问题，在世界各地，特别是在发达国家。许多类型的辅助生殖技术已经被开发出来，并被广泛用于治疗不孕不育。然而，妊娠结局需要进一步改善。了解怀孕期间子宫(母亲)和胚胎(胎儿)之间的串扰是至关重要的，这是一个非常复杂的事件。哺乳动物的子宫需要许多生理和形态变化才能发生与妊娠相关的事件，包括着床、蜕膜、胎盘形成和分娩。本文根据原始文献和综述文章，讨论了这些生殖事件 - ，特别是胚胎着床和蜕膜化 - 的分子机制方面的最新进展。在小鼠体内，胚胎着床和蜕膜化受到两种类固醇激素的调节：雌激素和孕激素。除了这些激素，细胞因子、细胞周期调节因子、生长因子和转录因子在小鼠的着床和蜕膜形成过程中也起着至关重要的作用。最近利用小鼠的基因操作进行的研究已经对胚胎植入和蜕膜形成的分子机制有了相当深入的了解。然而，由于大多数发现是基于小鼠，使用不同哺乳动物物种的比较研究将有助于更好地理解与生殖事件(包括胚胎植入)相关的物种依赖差异。
Human infertility has become a serious and social issue all over the world, especially in developed countries. Numerous types of assisted reproductive technology have been developed and are widely used to treat infertility. However, pregnancy outcomes require further improvement. It is essential to understand the cross‐talk between the uterus (mother) and the embryo (fetus) in pregnancy, which is a very complicated event. The mammalian uterus requires many physiological and morphological changes for pregnancy‐associated events, including implantation, decidualization, placentation, and parturition, to occur. Here is discussed recent advances in the knowledge of the molecular mechanisms underlying these reproductive events — in particular, embryonic implantation and decidualization — based on original and review articles. In mice, embryonic implantation and decidualization are regulated by two steroid hormones: estrogen and progesterone. Along with these hormones, cytokines, cell‐cycle regulators, growth factors, and transcription factors have essential roles in implantation and decidualization in mice. Recent studies using the gene manipulation of mice have given considerable insight into the molecular mechanisms underlying embryonic implantation and decidualization. However, as most of the findings are based on mice, comparative research using different mammalian species will be useful for a better understanding of the species‐dependent differences that are associated with reproductive events, including embryonic implantation.
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