Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE against aerosolized rabbitpox virus in a rabbit model.
Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE against aerosolized rabbitpox virus in a rabbit model.
复制标题
DOI：
10.1016/j.vaccine.2009.06.105
复制
发表时间：
2009-09-04
期刊：
影响因子：
5.5
通讯作者：
Nalca A
中科院分区：
文献类型：
--
作者：
Garza NL;Hatkin JM;Livingston V;Nichols DK;Chaplin PJ;Volkmann A;Fisher D;Nalca A
Infection of rabbits with aerosolized rabbitpox virus (RPXV) produces a disease similar to monkeypox and smallpox in humans and provides a valuable, informative model system to test medical countermeasures against orthopoxviruses. Due to the eradication of smallpox, the evaluation of the efficacy of new-generation smallpox vaccines depends on relevant well-developed animal studies for vaccine licensure. In this study, we tested the efficacy of IMVAMUNE® [modified vaccinia Ankara-Bavarian Nordic (MVA-BN®)] for protecting rabbits against aerosolized RPXV. Rabbits were vaccinated with either phosphate-buffered saline (PBS), Dryvax®, a single low dose of IMVAMUNE®, a single high dose of IMVAMUNE®, or twice with a high dose of IMVAMUNE®. Aerosol challenge with a lethal dose of RPXV was performed 4 weeks after the last vaccination. All PBS control animals succumbed to the disease or were euthanized because of the disease within 7 days postexposure. The rabbits vaccinated with Dryvax®, a low dose of IMVAMUNE®, or a single high dose of IMVAMUNE® showed minimal to moderate clinical signs of the disease, but all survived the challenge. The only clinical sign displayed by rabbits that had been vaccinated twice with a high dose of IMVAMUNE® was mild transient anorexia in just two out of eight rabbits. This study shows that IMVAMUNE® can be a very effective vaccine against aerosolized RPXV.
登录
查看更多内容
影响因子：
5.4
作者：
Davies, D. Huw;Wyatt, Linda S.;Felgner, Philip L.
通讯作者：
Felgner, Philip L.
影响因子：
15.9
作者：
Samuelsson, Christofer;Hausmann, Juergen;Hochrein, Hubertus
通讯作者：
Hochrein, Hubertus
影响因子：
5.4
作者：
Adams, Mathew M.;Rice, Amanda D.;Moyer, R. W.
通讯作者：
Moyer, R. W.
影响因子：
5.5
作者：
Frey, Sharon E.;Newman, Frances K.;Belshe, Robert B.
通讯作者：
Belshe, Robert B.
影响因子：
6.4
作者：
McClain, DJ;Harrison, S;Graham, JA
通讯作者：
Graham, JA