ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer.
ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer.
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ITGA3 与免疫细胞浸润相关，可作为乳腺癌的有利预后生物标志物
DOI：
10.3389/fonc.2021.658547
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Li Y;Li F;Bai X;Li Y;Ni C;Zhao X;Zhang D
ITGA 3是整合素家族的成员，是一种与细胞外基质（ECM）蛋白相互作用的细胞表面粘附分子。本研究旨在探讨ITGA 3表达在乳腺癌患者预后及临床诊断中的意义。方法应用Oncomine、人类蛋白质图谱（HPA）和UALCAN分析ITGA 3在多种肿瘤中的表达。采用PrognoScan、GEPIA、Kaplan-Meier逐步回归法和Easysurv法分析ITGA 3在某些癌症中的预后。基于TCGA数据，使用受试者工作特征（ROC）曲线来评估ITGA 3表达的诊断性能。使用cBio-Portal和MethSurv评估基因组机制。LinkedOmics、NetworkAnalyst和Metascape用于构建信令网络。TIMER是一个用于肿瘤浸润免疫细胞和肿瘤浸润淋巴细胞（TIL）综合分析的Web服务器。结果ITGA 3在正常乳腺组织中的表达水平高于乳腺癌组织。ITGA 3高表达与乳腺癌患者预后良好相关。ROC曲线分析显示ITGA 3具有显著的诊断价值。基因组分析显示，ITGA 3启动子甲基化导致转录沉默，这可能是BRCA中ITGA 3下调的机制之一。免疫浸润分析表明ITGA 3可能参与免疫细胞的募集。结论ITGA 3可作为乳腺癌诊断和预后评估的新生物标志物。此外，ITGA 3参与ECM调节和免疫细胞浸润。
Background ITGA3 is a member of the integrin family, a cell surface adhesion molecule that can interact with extracellular matrix (ECM) proteins. The purpose of this study was to explore the significance of ITGA3 expression in the prognosis and clinical diagnosis of breast cancer patients. Methods Oncomine, the Human Protein Atlas (HPA) and UALCAN were used to analyze the expression of ITGA3 in various cancers. PrognoScan, GEPIA, Kaplan–Meier plotter and Easysurv were utilized to analyze the prognosis of ITGA3 in certain cancers. Based on TCGA data, a receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance of ITGA3 expression. cBio-Portal and MethSurv were used to evaluate the genomic mechanism. LinkedOmics, NetworkAnalyst and Metascape were used to build the signaling network. TIMER is a web server for comprehensive analysis of tumor infiltrating immune cells and tumor infiltrating lymphocytes (TILs). Results The expression of ITGA3 in normal breast tissues was greater than that in breast cancer tissues at both the mRNA and protein levels. High expression of ITGA3 was associated with better prognosis of breast cancer patients. ROC analysis indicated that ITGA3 had significant diagnostic value. Genomic analysis revealed that promoter methylation of ITGA3 leads to transcriptional silencing, which may be one of the mechanisms underlying ITGA3 downregulation in BRCA. Immune infiltration analysis showed that ITGA3 may be involved in the recruitment of immune cells. Conclusions This study identified ITGA3 as a novel biomarker to estimate the diagnosis and prognosis of breast cancer. In addition, ITGA3 is involved in ECM regulation and immune cell infiltration.
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DOI：
10.1084/jem.20111426
发表时间：
2012-07-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hyun YM;Sumagin R;Sarangi PP;Lomakina E;Overstreet MG;Baker CM;Fowell DJ;Waugh RE;Sarelius IH;Kim M
通讯作者：
Kim M
影响因子：
20.3
作者：
Kryczek, Ilona;Banerjee, Mousumi;Zou, Weiping
通讯作者：
Zou, Weiping
DOI：
10.1039/c5ib00040h
发表时间：
2015-10
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Acerbi I;Cassereau L;Dean I;Shi Q;Au A;Park C;Chen YY;Liphardt J;Hwang ES;Weaver VM
通讯作者：
Weaver VM
影响因子：
8
作者：
Ahirwar DK;Nasser MW;Ouseph MM;Elbaz M;Cuitiño MC;Kladney RD;Varikuti S;Kaul K;Satoskar AR;Ramaswamy B;Zhang X;Ostrowski MC;Leone G;Ganju RK
通讯作者：
Ganju RK
影响因子：
50.3
作者：
Cassetta, Luca;Fragkogianni, Stamatina;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.