Splice variation of the mu-opioid receptor and its effect on the action of opioids
Splice variation of the mu-opioid receptor and its effect on the action of opioids
复制标题
mu-阿片受体的剪接变异及其对阿片类药物作用的影响
作者：
S. Gretton;J. Droney
一个人对阿片类药物的反应受到遗传、分子和表型因素的复杂组合的影响。对μ阿片类药物反应的个体内和个体间差异已导致存在μ阿片受体亚型的建议。科学家现在已经证明，μ阿片受体亚型存在，并且它们通过促进蛋白质多样性的机制发生，称为选择性剪接。μ阿片类药物差异激活剪接变体的能力可以解释μ阿片类药物之间观察到的一些临床差异。本文探讨了如何通过不同的μ阿片受体结合，通过差异受体激活，以及作为位于区域和细胞水平的变异体的不同分布的结果，发生由μ阿片类剪接变异体的差异激活。
Summary points An individual’s response to opioids is influenced by a complex combination of genetic, molecular and phenotypic factors. Intra- and inter-individual variations in response to mu opioids have led to the suggestion that mu-opioid receptor subtypes exist. Scientists have now proven that mu-opioid receptor subtypes exist and that they occur through a mechanism promoting protein diversity, called alternative splicing. The ability of mu opioids to differentially activate splice variants may explain some of the clinical differences observed between mu opioids. This article examines how differential activation of splice variants by mu opioids occurs through alternative mu-opioid receptor binding, through differential receptor activation, and as a result of the distinct distribution of variants located regionally and at the cellular level.
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大鼠脑 mu 阿片受体的纯化和部分氨基酸序列。
DOI：
--
发表时间：
1993
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Eppler,CM;Hulmes,JD;Wang,JB;Johnson,B;Corbett,M;Luthin,DR;Uhl,GR;Linden,J
通讯作者：
Linden,J
DOI：
10.1073/pnas.90.21.9954
发表时间：
1993-11-01
影响因子：
11.1
作者：
MENG, F;XIE, GX;AKIL, H
通讯作者：
AKIL, H
影响因子：
5
作者：
Ling,GS;Spiegel,K;Nishimura,SL;Pasternak,GW
通讯作者：
Pasternak,GW
影响因子：
4.7
作者：
Pasternak GW
通讯作者：
Pasternak GW
影响因子：
56.9
作者：
EVANS, CJ;KEITH, DE;EDWARDS, RH
通讯作者：
EDWARDS, RH