Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing.
Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing.
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DOI：
10.1016/j.physbeh.2014.09.001
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发表时间：
2015-01
影响因子：
2.9
通讯作者：
Bimonte-Nelson HA
中科院分区：
文献类型：
--
作者：
Mennenga SE;Gerson JE;Dunckley T;Bimonte-Nelson HA
去氢骆驼蓬碱是一种天然存在的单胺氧化酶抑制剂，最近已被证明可选择性抑制双特异性酪氨酸-（Y）-磷酸化调节激酶1A（DYRK 1A）。我们研究了1 mg（低）和5 mg（高）去氢骆驼蓬碱的认知效果，使用延迟匹配样本（DMS）的不对称3选择水迷宫任务，以评估空间工作和最近的记忆，和Morris水迷宫任务（MM），以测试空间参考记忆。动物也进行了测试，在可见的平台任务，水逃生任务具有相同的电机，动机，和强化组件作为其他任务用于评估认知，但不同的是它的更大的简单性和平台是可见的水面以上。Harmine-high给药动物的一个子集在所有行为任务中显示出明显的运动障碍，可见平台任务证实缺乏执行水迷宫测试程序部分的能力。从高剂量组中排除无法执行游泳任务程序部分的动物后，发现高剂量和低剂量去氢骆驼蓬碱给药均增强了DMS测试后半部分的性能，但对MM性能无影响。因此，本研究证明了在研究动物认知时确认运动和视觉能力的重要性，并验证了为期一天的可见平台任务作为完成游泳任务所需的程序组件执行能力的可靠措施。
Harmine is a naturally occurring monoamine oxidase inhibitor that has recently been shown to selectively inhibit the dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A). We investigated the cognitive effects of 1 mg (low) Harmine and 5 mg (high) Harmine using the delayed-match-to-sample (DMS) asymmetrical 3-choice water maze task to evaluate spatial working and recent memory, and the Morris water maze task (MM) to test spatial reference memory. Animals were also tested on the visible platform task, a water-escape task with the same motor, motivational, and reinforcement components as the other tasks used to evaluate cognition, but differing in its greater simplicity and that the platform was visible above the surface of the water. A subset of the Harmine-high treated animals showed clear motor impairments on all behavioral tasks, and the visible platform task confirmed a lack of competence to perform the procedural components of water maze testing. After excluding animals from the high dose group that could not perform the procedural components of a swim task, it was revealed that both high- and low-dose treatment with Harmine enhanced performance on the latter portion of DMS testing, but had no effect on MM performance. Thus, this study demonstrates the importance of confirming motor and visual competence when studying animal cognition, and verifies the one-day visible platform task as a reliable measure of ability to perform the procedural components necessary for completion of a swim task.
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过表达的DyRK1a蛋白在唐氏综合症的神经原纤维变性早期发作中的作用。
影响因子：
12.7
作者：
Wegiel J;Dowjat K;Kaczmarski W;Kuchna I;Nowicki K;Frackowiak J;Mazur Kolecka B;Wegiel J;Silverman WP;Reisberg B;Deleon M;Wisniewski T;Gong CX;Liu F;Adayev T;Chen-Hwang MC;Hwang YW
通讯作者：
Hwang YW
影响因子：
2.7
作者：
Hunter, CL;Bimonte, HA;Granholm, ACE
通讯作者：
Granholm, ACE
DOI：
10.1073/pnas.87.23.9368
发表时间：
1990-12-01
影响因子：
11.1
作者：
ALBORES, R;NEAFSEY, EJ;COLLINS, MA
通讯作者：
COLLINS, MA
影响因子：
2.9
作者：
Du, W;Aloyo, VJ;Harvey, JA
通讯作者：
Harvey, JA
影响因子：
3.5
作者：
Park, Joongkyu;Yang, Eun Jin;Chung, Kwang Chul
通讯作者：
Chung, Kwang Chul