Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using ASL-MRI.
Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using ASL-MRI.
复制标题
使用ASL-MRI，在大鼠中，进入脑血流与心室纤颤后的脑血流的全球和区域差异。
DOI：
10.1016/j.resuscitation.2014.03.314
复制
发表时间：
2014-07
期刊：
影响因子：
6.5
通讯作者：
Kochanek PM
中科院分区：
文献类型：
--
作者：
Drabek T;Foley LM;Janata A;Stezoski J;Hitchens TK;Manole MD;Kochanek PM
室颤性心脏骤停（VFCA）和窒息性心脏骤停（ACA）是CA的常见原因。然而，只有孤立的报告比较了不同类型的CA后的脑血流（CBF）再灌注模式，甚至更少的报告使用的方法，允许连续和区域评估CBF。我们假设CBF的再灌注模式在不同类型的实验性CA之间会有所不同。在一项前瞻性随机区组研究中，芬太尼麻醉的成年大鼠进行8分钟的VFCA或ACA。然后用肾上腺素、碳酸氢盐、手动胸外按压和机械通气复苏大鼠。自主循环恢复后，通过动脉自旋标记磁共振成像（ASL-MRI）连续评估1 h复苏时间（RT）内皮质、丘脑、海马和杏仁核/梨状核复合体的CBF。ACA和VFCA都产生了显着的时间和地区差异CBF。两种模型中的所有区域均显示出随时间的显著变化（p<0.01），具有早期高灌注和延迟低灌注。ACA导致皮质和丘脑中的早期过度灌注（均p<0.05，与杏仁核/梨状复合体相比）。相比之下，VFCA仅在皮质中诱导早期过度灌注（p<0.05 vs.其他区域）。在ACA之后，过度灌注延长，在RT 7分钟时达到峰值（RT 7; 199% vs. BL，基线，在皮质中和在丘脑中为201%，p<0.05），然后在RT 15时恢复接近BL。相比之下，VFCA模型诱导轻度充血，在RT 7达到峰值（皮质中为BL的141%）。ACA和VFCA均显示延迟性低灌注（ACA，在海马和杏仁核/梨状复合体中低于BL约30%，p<0.05; VFCA，在海马和杏仁核/梨状复合体中低于BL 34-41%，p<0.05）。总之，ACA和VFCA在成年大鼠CBF产生显着的区域和时间差异。在ACA，过度灌注是最明显的皮质和丘脑。在VFCA中，变化更为温和，仅在皮质中观察到过度灌注。两种损伤导致所有区域的延迟灌注不足。早期高灌注和延迟低灌注可能是重要的治疗靶点。本研究已获得匹兹堡大学IACUC 1008816-1的批准。
Both ventricular fibrillation cardiac arrest (VFCA) and asphyxial cardiac arrest (ACA) are frequent causes of CA. However, only isolated reports compared cerebral blood flow (CBF) reperfusion patterns after different types of CA, and even fewer reports used methods that allow serial and regional assessment of CBF. We hypothesized that the reperfusion patterns of CBF will differ between individual types of experimental CA. In a prospective block-randomized study, fentanyl-anesthetized adult rats were subjected to 8 min VFCA or ACA. Rats were then resuscitated with epinephrine, bicarbonate, manual chest compressions and mechanical ventilation. After the return of spontaneous circulation, CBF was then serially assessed via arterial spin-labeling magnetic resonance imaging (ASL-MRI) in cortex, thalamus, hippocampus and amygdala/piriform complex over 1 h resuscitation time (RT). Both ACA and VFCA produced significant temporal and regional differences in CBF. All regions in both models showed significant changes over time (p<0.01), with early hyperperfusion and delayed hypoperfusion. ACA resulted in early hyperperfusion in cortex and thalamus (both p<0.05 vs. amygdala/piriform complex). In contrast, VFCA induced early hyperperfusion only in cortex (p<0.05 vs. other regions). Hyperperfusion was prolonged after ACA, peaking at 7 min RT (RT7; 199% vs. BL, Baseline, in cortex and 201% in thalamus, p<0.05), then returning close to BL at ~ RT15. In contrast, VFCA model induced mild hyperemia, peaking at RT7, (141% vs. BL in cortex). Both ACA and VFCA showed delayed hypoperfusion (ACA, ~30% below BL in hippocampus and amygdala/piriform complex, p<0.05; VFCA, 34–41% below BL in hippocampus and amygdala/piriform complex, p<0.05). In conclusion, both ACA and VFCA in adult rats produced significant regional and temporal differences in CBF. In ACA, hyperperfusion was most pronounced in cortex and thalamus. In VFCA, the changes were more modest, with hyperperfusion seen only in cortex. Both insults resulted in delayed hypoperfusion in all regions. Both early hyperperfusion and delayed hypoperfusion may be important therapeutic targets. This study was approved by the University of Pittsburgh IACUC 1008816-1.
登录
查看更多内容
影响因子：
3.3
作者：
Lin HW;Defazio RA;Della-Morte D;Thompson JW;Narayanan SV;Raval AP;Saul I;Dave KR;Perez-Pinzon MA
通讯作者：
Perez-Pinzon MA
影响因子：
8.8
作者：
Janata, Andreas;Magnet, Ingrid A. M.;Kochanek, Patrick M.
通讯作者：
Kochanek, Patrick M.
DOI：
10.1164/ajrccm.164.7.2007083
发表时间：
2001-10-01
影响因子：
24.7
作者：
Kamohara, T;Weil, MH;Bisera, J
通讯作者：
Bisera, J
影响因子：
3.3
作者：
GOPLERUD, JM;WAGERLE, LC;DELIVORIAPAPADOPOULOS, M
通讯作者：
DELIVORIAPAPADOPOULOS, M
影响因子：
8.3
作者：
LEONOV, Y;STERZ, F;OKU, K
通讯作者：
OKU, K