Merging the Versatile Functionalities of Boronic Acid with Peptides.
Merging the Versatile Functionalities of Boronic Acid with Peptides.
复制标题
将硼酸的多功能功能与肽相结合
DOI：
10.3390/ijms222312958
复制
发表时间：
2021-11-30
影响因子：
5.6
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Tan Y;Wu J;Song L;Zhang M;Hipolito CJ;Wu C;Wang S;Zhang Y;Yin Y
多肽具有易于合成、水溶性、生物相容性和通常无毒等优点。因此，硼酸已被广泛地与肽结合，目的是发现具有新的生物活性的肽配体，这一努力导致了广泛的应用。本文以硼酸与多肽的结合为切入点，综述了最新的研究进展，重点介绍了硼酸的多功能和强大的功能。本文综述了多肽硼酸在药物化学和化学生物学中的应用，包括共价可逆酶抑制剂的鉴定、蛋白质或癌细胞表面聚糖的识别和检测、sirna的传递、pH响应装置的开发以及RNA或细菌表面的识别。此外，我们讨论了硼酸介导的肽环化和肽修饰，以及肽硼酸的简便化学合成，这为开发越来越多的肽硼酸铺平了道路。
Peptides inherently feature the favorable properties of being easily synthesized, water-soluble, biocompatible, and typically non-toxic. Thus, boronic acid has been widely integrated with peptides with the goal of discovering peptide ligands with novel biological activities, and this effort has led to broad applications. Taking the integration between boronic acid and peptide as a starting point, we provide an overview of the latest research advances and highlight the versatile and robust functionalities of boronic acid. In this review, we summarize the diverse applications of peptide boronic acids in medicinal chemistry and chemical biology, including the identification of covalent reversible enzyme inhibitors, recognition, and detection of glycans on proteins or cancer cell surface, delivery of siRNAs, development of pH responsive devices, and recognition of RNA or bacterial surfaces. Additionally, we discuss boronic acid-mediated peptide cyclization and peptide modifications, as well as the facile chemical synthesis of peptide boronic acids, which paved the way for developing a growing number of peptide boronic acids.
登录
查看更多内容
影响因子：
3.4
作者：
Ballatore, Carlo;Huryn, Donna M.;Smith, Amos B., III
通讯作者：
Smith, Amos B., III
影响因子：
16.6
作者：
Diaz, Diego B.;Scully, Conor C. G.;Yudin, Andrei K.
通讯作者：
Yudin, Andrei K.
硼酸官能化肽基合成凝集素：组合库设计，肽测序和选择性糖蛋白识别。
影响因子：
--
作者：
Bicker, Kevin L.;Sun, Jing;Lavigne, John J.;Thompson, Paul R.
通讯作者：
Thompson, Paul R.
影响因子：
16.6
作者：
Bandyopadhyay, Anupam;McCarthy, Kelly A.;Kelly, Michael A.;Gao, Jianmin
通讯作者：
Gao, Jianmin
影响因子：
8.4
作者：
Faustino H;Silva MJSA;Veiros LF;Bernardes GJL;Gois PMP
通讯作者：
Gois PMP