Reduced serum corin levels in patients with osteoporosis.
Reduced serum corin levels in patients with osteoporosis.
复制标题
骨质疏松症患者血清corin水平降低。
DOI：
10.1016/j.cca.2013.09.007
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发表时间：
2013-11
影响因子：
5
通讯作者：
Dong, Ningzheng
中科院分区：
文献类型：
--
作者：
Liu, Meng;Fang, Chaodong;Wu, Qingyu;Dong, Ningzheng
背景Corin是一种激活利钠肽的心肌蛋白酶。Corin还在经历成骨分化的软骨细胞和骨髓来源的间充质干细胞中表达，表明corin在骨形成和体内平衡中的潜在作用。我们用ELISA法检测了134名健康对照者和53名骨质减少和骨质疏松患者血清中corin和骨钙素的水平，结果骨量减少和骨质疏松患者血清corin水平分别为510 ± 228和478 ± 183 pg/ml，均显著低于健康对照组（682 ± 240 pg/ml）（P均< 0.001）。血清corin水平降低，发现在男性和女性患者。在多元线性回归分析中，骨密度被确定为血清corin水平的独立预测因子。在骨量减少和骨质疏松症患者，但不是正常对照组，血清corin和骨钙素levels.ConclusionSerum corin水平降低，骨质疏松症患者和减少与高骨转换率之间呈负相关。低血清corin水平可能反映骨质疏松患者骨稳态受损。
BackgroundCorin is a cardiac protease that activates the natriuretic peptides. Corin is also expressed in chondrocytes and bone marrow-derived mesenchymal stem cells that undergo osteogenic differentiation, suggesting a potential role of corin in bone formation and homeostasis.MethodsTo test if corin levels are altered in patients with bone disease, we used ELISA to measure corin and osteocalcin levels in serum samples from healthy controls (n = 134) and patients with osteopenia (n = 53) and osteoporosis (n = 101).ResultsIn patients with osteopenia and osteoporosis, serum corin levels were 510 ± 228 and 478 ± 183 pg/ml, respectively, which were significantly lower than that in healthy controls (682 ± 240 pg/ml) (bothpvalues < 0.001). The reduced serum corin levels were found in both male and female patients. In multiple linear regression analysis, bone mineral density was identified as an independent predictor for serum corin levels. In patients with osteopenia and osteoporosis, but not normal controls, a negative correlation was found between serum corin and osteocalcin levels.ConclusionSerum corin levels were reduced in patients with osteoporosis and the reduction was associated with high rates of bone turnover. Low serum corin levels may reflect impaired bone homeostasis in patients with osteoporosis.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.cca.2011.10.032
发表时间：
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期刊：
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影响因子：
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发表时间：
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影响因子：
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