Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder
Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder
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腹侧被盖区功能障碍和多巴胺能稳态破坏：对创伤后应激障碍的影响
DOI：
10.1007/s12035-020-02278-6
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发表时间：
2021-01
影响因子：
5.1
通讯作者：
Changzheng Zhang
中科院分区：
文献类型：
--
作者：
Peiling Zhou;Meiping Deng;Jiashan Wu;Qinghui Lan;Huifang Yang;Changzheng Zhang
创伤后应激障碍（Post-traumatic stress disorder，PTSD）是一种以创伤性事件的侵入性回忆、回避行为、对事件相关线索的过度唤醒、认知障碍和情绪失调为特征的衰弱性精神疾病。越来越多的临床前和临床证据表明腹侧被盖区（VTA）多巴胺能系统功能障碍与PTSD的发病机制有关。本文综述了多巴胺能稳态障碍与PTSD之间关系的最新进展，包括特异性多巴胺能基因变异对疾病易感性的贡献，腹侧被盖区多巴胺神经元活性的改变，多巴胺能传递的失调，以及针对多巴胺能系统的PTSD的潜在药理学和心理学干预。深入了解创伤后应激障碍的病因是至关重要的发展创新的风险评估，诊断和治疗策略后的创伤事件。
AbstractPost-traumatic stress disorder (PTSD) is a debilitating psychiatric condition characterized by intrusive recollections of the traumatic event, avoidance behaviors, hyper-arousal to event-related cues, cognitive disruption, and mood dysregulation. Accumulating preclinical and clinical evidence implicates dysfunction of the ventral tegmental area (VTA) dopaminergic system in PTSD pathogenesis. This article reviews recent advances in our knowledge of the relationship between dopaminergic dyshomeostasis and PTSD, including the contributions of specific dopaminergic gene variants to disease susceptibility, alterations in VTA dopamine neuron activity, dysregulation of dopaminergic transmission, and potential pharmacological and psychological interventions for PTSD targeting the dopaminergic system. An in-depth understanding of PTSD etiology is crucial for the development of innovative risk assessment, diagnostic, and treatment strategies following traumatic events.
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影响因子：
--
作者：
Mirnesa Muminović Umihanić;R. Babić;N. Kravić;E. Avdibegović;A. Džubur Kulenović;F. Agani;M. Jakovljevič;D. Babic;A. Kučukalić;S. Kučukalić;Emina Šabić Džananović;A. Bravo Mehmedbašić;Aferdita Goci Uka;S. Haxhibeqiri;B. Hoxha;V. Haxhibeqiri;B. Aukst Margetić;N. Jakšić;Ana Čima Franc;D. Rudan;M. Pavlović;Elma Ferić Bojić;D. Marjanovic;N. Božina;C. Ziegler;C. Wolf;B. Warrings;K. Domschke;J. Deckert;O. Sinanović
通讯作者：
Mirnesa Muminović Umihanić;R. Babić;N. Kravić;E. Avdibegović;A. Džubur Kulenović;F. Agani;M. Jakovljevič;D. Babic;A. Kučukalić;S. Kučukalić;Emina Šabić Džananović;A. Bravo Mehmedbašić;Aferdita Goci Uka;S. Haxhibeqiri;B. Hoxha;V. Haxhibeqiri;B. Aukst Margetić;N. Jakšić;Ana Čima Franc;D. Rudan;M. Pavlović;Elma Ferić Bojić;D. Marjanovic;N. Božina;C. Ziegler;C. Wolf;B. Warrings;K. Domschke;J. Deckert;O. Sinanović
影响因子：
7.8
作者：
McLaughlin T;Blum K;Oscar-Berman M;Febo M;Agan G;Fratantonio JL;Simpatico T;Gold MS
通讯作者：
Gold MS
DOI：
10.1038/s41583-018-0039-7
发表时间：
2018-09
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Fenster RJ;Lebois LAM;Ressler KJ;Suh J
通讯作者：
Suh J
影响因子：
4.7
作者：
Curry DW;Young MB;Tran AN;Daoud GE;Howell LL
通讯作者：
Howell LL
多巴胺 D3 受体在缓解创伤后应激障碍动物模型行为缺陷中的作用
DOI：
10.1016/j.pnpbp.2018.03.001
发表时间：
2018-03
影响因子：
5.6
作者：
Dake Song;Yaping Ge;Zhaodi Chen;Chao Shang;Ying Guo;Taiyun Zhao;Yunfeng Li;Ning Wu;Rui Song;Jin Li
通讯作者：
Jin Li