Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man.

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man.
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DOI:
10.1038/s41583-018-0039-7
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发表时间:
2018-09
期刊:
Nature reviews. Neuroscience
影响因子:
--
通讯作者:
Suh J
Suh J
中科院分区:
其他
文献类型:
--
作者:
Fenster RJ;Lebois LAM;Ressler KJ;Suh J

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创伤后应激障碍(PTSD)是一种普遍的、使人衰弱的,有时甚至是致命的心理创伤的后果。虽然对某些人有有效的治疗方法,但它们是有限的。因此,非常需要新的干预、治疗和预防方法。在过去的几年里,该领域迅速发展了对创伤后应激障碍背后的功能失调脑回路的更多理解,这种理解的转变是由技术革命实现的,技术革命允许观察和干扰被认为是创伤后应激障碍相关症状背后的宏电路和微电路。这些进步使我们获得了更多关于创伤后应激障碍的转化知识,为风险和恢复力的机制提供了进一步的见解,并为治疗发现提供了有希望的途径。
Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly consequence of exposure to severe psychological trauma. Although effective treatments exist for some individuals, they are limited. New approaches to intervention, treatment and prevention are therefore much needed. In the past few years, the field has rapidly developed a greater understanding of the dysfunctional brain circuits underlying PTSD, a shift in understanding that has been made possible by technological revolutions that have allowed the observation and perturbation of the macrocircuits and microcircuits thought to underlie PTSD-related symptoms. These advances have allowed us to gain a more translational knowledge of PTSD, have provided further insights into the mechanisms of risk and resilience and offer promising avenues for therapeutic discovery.
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