High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy.
High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy.
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DOI：
10.1016/j.neuroimage.2021.118866
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发表时间：
2022-03
期刊：
影响因子：
5.7
通讯作者：
Bonilha L
中科院分区：
文献类型：
--
作者：
Gleichgerrcht E;Keller SS;Bryant L;Moss H;Kellermann TS;Biswas S;Marson AG;Wilmskoetter J;Jensen JH;Bonilha L
弥散磁共振成像（dMRI）纤维束成像在表征癫痫患者异常脑网络重组模式方面发挥了关键作用。然而，dMRI纤维束成像的准确性受到白色物质组织的复杂生物物理特性的阻碍。高b值弥散成像通过更好地分离轴突通路克服了这一限制。在这项研究中，我们引入纤维束成像（FBI），高b值的方法，排除非轴突信号，以确定癫痫患者的非典型神经元网络。具体而言，我们比较了从多种弥散纤维束成像方法（弥散张量成像，弥散峰度成像，FBI）获得的网络特性，以评估网络重排在药物反应性与药物难治性局灶性癫痫成人中的病理生理相关性。我们发现，耐药性癫痫与基于FBI的纤维束成像检测到的全球网络隔离增加有关。我们建议探索FBI作为一种临床可行的替代方案，以量化拓扑变化，可用于跟踪疾病进展并告知临床结果。
Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
局灶性癫痫中的纤维球白质建模。
影响因子：
4.8
作者：
Bryant L;McKinnon ET;Taylor JA;Jensen JH;Bonilha L;de Bezenac C;Kreilkamp BAK;Adan G;Wieshmann UC;Biswas S;Marson AG;Keller SS
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影响因子：
3.3
作者：
Kellner, Elias;Dhital, Bibek;Reisert, Marco
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影响因子：
4.6
作者：
Alizadeh, Mahdi;Kozlowski, Lauren;Sharan, Ashwini
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Sharan, Ashwini