Trend of Olfactory and Gustatory Dysfunction in COVID-19 Patients in a Quarantine Facility.
Trend of Olfactory and Gustatory Dysfunction in COVID-19 Patients in a Quarantine Facility.
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隔离设施中的COVID-19患者嗅觉和味道功能障碍的趋势。
DOI：
10.3346/jkms.2020.35.e375
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发表时间：
2020-10-26
影响因子：
4.5
通讯作者：
Choi WS
中科院分区：
文献类型：
--
作者：
Seo MY;Seok H;Hwang SJ;Choi HK;Jeon JH;Sohn JW;Park DW;Lee SH;Choi WS
据报道，嗅觉和味觉功能障碍是2019年冠状病毒病的特征症状(新冠肺炎)。这项研究使用经过验证的评估方法评估了轻度新冠肺炎患者的嗅觉和味觉功能障碍。在韩国京基国际生活与治疗支持中心隔离的轻度新冠肺炎患者中进行了一项前瞻性监测研究。用韩国版嗅觉障碍问卷(QOD)和跨文化嗅觉辨别测验(CC-SIT)评估嗅觉功能。用11分Likert评分和6-丙基硫氧尿嘧啶、苯硫脲和对照试纸评估味觉功能。所有患者均接受鼻、口腔内窥镜检查。在LTSC的62名患者中，15名患者(24.2%)在入院时主诉嗅觉或味觉功能障碍。在接受功能评估的10名患者中，4名患者没有一般症状，2名患者没有症状。Qod阴性陈述平均短文分为13±6，Qod视觉类比表分为4.7±3.6。CC-SIT评分平均为(8±2)分。无1例患者在内窥镜检查中出现与嗅觉障碍相关的解剖异常。平均Likert功能评分为(8±2)分，所有患者口腔内均未见异常病变。在轻度新冠肺炎患者中，嗅觉和味觉功能障碍的患病率为24.2%。所有患者都因感觉神经嗅觉功能障碍而出现嗅觉减退，这一点通过有效的嗅觉和味觉评估方法和内窥镜检查得到证实。嗅觉和味觉功能障碍可能是轻度新冠肺炎的特征指标。
Olfactory and gustatory dysfunction has been reported as characteristic symptoms of coronavirus disease 2019 (COVID-19). This study evaluated olfactory and gustatory dysfunction in mild COVID-19 patients using validated assessment methods. A prospective surveillance study was conducted for mild COVID-19 patients who were isolated at the Gyeonggi International Living and Treatment Support Center (LTSC), Korea. Olfactory function was assessed using the Korean version of the Questionnaire of Olfactory Disorders (QOD) and Cross-Cultural Smell Identification Test (CC-SIT). Gustatory function was assessed using an 11-point Likert scale and 6-n-propylthiouracil, phenylthiocarbamide, and control strips. All patients underwent nasal and oral cavity endoscopic examination. Of the 62 patients at the LTSC, 15 patients (24.2%) complained of olfactory or gustatory dysfunction on admission. Four of 10 patients who underwent functional evaluation did not have general symptoms and 2 were asymptomatic. The mean short version of QOD-negative statements and QOD-visual analogue scale scores were 13 ± 6 and 4.7 ± 3.6, respectively. The mean CC-SIT score was 8 ± 2. No patients showed anatomical abnormalities associated with olfactory dysfunction on endoscopic examination. The mean Likert scale score for function was 8 ± 2, and there were no abnormal lesions in the oral cavity of any patient. The prevalence of olfactory and gustatory dysfunction was 24.2% in mild COVID-19 patients. All patients had hyposmia due to sensorineural olfactory dysfunction, which was confirmed using validated olfactory and gustatory evaluation methods and endoscopic examination. Olfactory and gustatory dysfunction may be characteristic indicators of mild COVID-19.
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1.8
作者：
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