Recent concepts of ovarian carcinogenesis: type I and type II.
Recent concepts of ovarian carcinogenesis: type I and type II.
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DOI：
10.1155/2014/934261
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发表时间：
2014
影响因子：
--
通讯作者：
Konishi I
中科院分区：
文献类型：
--
作者：
Koshiyama M;Matsumura N;Konishi I
I型卵巢肿瘤，其中卵巢的前体病变已被清楚描述，包括子宫内膜样癌、透明细胞癌、粘液癌、低度浆液性癌和移行细胞癌，而II型肿瘤，其中此类病变尚未被清楚描述，并且肿瘤可能从输卵管从头发展和/或卵巢表面上皮，包括高级浆液性癌、未分化癌和癌肉瘤。游离铁浓度通过诱导持续的氧化应激与癌症发展相关，从而显著影响由类黄嘌呤囊肿引起的类黄嘌呤和透明细胞癌（CCC）的癌变。一部分粘液癌与卵巢畸胎瘤相关，但是大多数卵巢畸胎瘤不含任何畸胎瘤成分。其起源的其他理论包括表面上皮包涵体的粘液性化生、子宫内膜异位症和布伦纳肿瘤。低级别浆液性癌被认为是从良性浆液性囊腺瘤逐步演变为浆液性交界性肿瘤（SBT）。关于高级别浆液性癌，输卵管上皮与输卵管浆膜间皮的连接处的浆液性输卵管上皮内癌（STIC），称为“输卵管腹膜连接处”（TPJ），由于其位置而经历恶性转化，并转移到附近的卵巢和周围的盆腔腹膜。其他的起源理论包括卵巢门细胞。
Type I ovarian tumors, where precursor lesions in the ovary have clearly been described, include endometrioid, clear cell, mucinous, low grade serous, and transitional cell carcinomas, while type II tumors, where such lesions have not been described clearly and tumors may develop de novo from the tubal and/or ovarian surface epithelium, comprise high grade serous carcinomas, undifferentiated carcinomas, and carcinosarcomas. The carcinogenesis of endometrioid and clear cell carcinoma (CCC) arising from endometriotic cysts is significantly influenced by the free iron concentration, which is associated with cancer development through the induction of persistent oxidative stress. A subset of mucinous carcinomas develop in association with ovarian teratomas; however, the majority of these tumors do not harbor any teratomatous component. Other theories of their origin include mucinous metaplasia of surface epithelial inclusions, endometriosis, and Brenner tumors. Low grade serous carcinomas are thought to evolve in a stepwise fashion from benign serous cystadenoma to a serous borderline tumor (SBT). With regard to high grade serous carcinoma, the serous tubal intraepithelial carcinomas (STICs) of the junction of the fallopian tube epithelium with the mesothelium of the tubal serosa, termed the “tubal peritoneal junction” (TPJ), undergo malignant transformation due to their location, and metastasize to the nearby ovary and surrounding pelvic peritoneum. Other theories of their origin include the ovarian hilum cells.
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发表时间：
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