Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study.
Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study.
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DOI：
10.1155/2021/5558138
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发表时间：
2021
影响因子：
3.1
通讯作者：
Ma C
中科院分区：
文献类型：
--
作者：
Xu Z;Wu S;Li X;Liu C;Fan S;Ma C
经椎间孔类固醇注射广泛用于治疗椎间盘突出症，但它会带来并发症。相比之下，富含血小板血浆（PRP）注射已用于治疗肌肉骨骼疾病，可能是另一种选择。本研究旨在比较超声引导下经椎间孔注射 PRP 和类固醇治疗因腰椎间盘突出症引起的根性疼痛的患者的疗效和安全性。在一项随机对照试验中，总共 124 名因腰椎间盘突出症而遭受根性疼痛的患者接受了超声引导下经椎间孔注射 PRP（n = 61）或类固醇（n = 63）。术前及术后1周、1个月、3个月、6个月和12个月对患者进行视觉模拟量表(VAS)、压痛阈值(PPTs)、Oswestry残疾指数(ODI)以及36项简短健康调查(SF-36)的身体功能(PF)和身体疼痛(BP)领域的评估。术前和术后12个月获得F波频率和潜伏期。两组间年龄、性别无统计学差异。两组患者SF-36的VAS、PPT、ODI、PF和BP较术前数据与术后1个月数据均有统计学意义的显着改善，并保持1年。术后 1 年，两组的 F 波频率和潜伏期均显着改善。在 1 年的随访期间，PRP 组和类固醇组之间的所有上述评估均未发现组间差异显着。没有并发症的报道。结果显示，使用 PRP 和类固醇经椎间孔注射治疗腰椎间盘突出症的效果相似，表明 PRP 注射可能作为一种更安全的替代方案。该试验已在中国临床试验注册中心注册（ChiCTR-INR-17011825）。
Transforaminal steroid injection is extensively used as a treatment in cases of herniated disc, but it is associated with complications. In comparison, platelet-rich plasma (PRP) injection has been used in musculoskeletal disorders and could be another option. This study is aimed at comparing the efficacy and safety aspects between ultrasound-guided transforaminal injections of PRP and steroid in patients who suffer from radicular pain due to lumbar disc herniation. In a randomized controlled trial, ultrasound-guided transforaminal injections of either PRP (n = 61) or steroid (n = 63) were administered to a total of 124 patients who suffer from radicular pain due to lumbar disc herniation. Patients were assessed by the visual analogue scale (VAS), pressure pain thresholds (PPTs), Oswestry disability index (ODI), and the physical function (PF) and bodily pain (BP) domains of the 36-item short form health survey (SF-36) before operation and 1 week, 1 month, 3 months, 6 months, and 12 months after operation. The rate and latency of F-wave were obtained before operation and 12 months postoperation. There was no statistical difference in terms of age and sex between both groups. Statistically significant improvements from the patients' data before operation to data obtained 1-month postoperation were observed in VAS, PPTs, ODI, and PF and BP of SF-36 in both groups and kept for 1 year. F-wave rate and latency were improved significantly at 1-year postoperation in both groups. Intergroup differences during follow-ups over a period of 1 year were not found to be significant in all the above assessment between the PRP and steroid groups. No complications were reported. The results showed similar outcome for both transforaminal injections using PRP and steroid in the treatment of lumbar disc herniation, suggesting the possible application of PRP injection as a safer alternative. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR-INR-17011825).
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影响因子：
2.3
作者：
Akeda K;Ohishi K;Masuda K;Bae WC;Takegami N;Yamada J;Nakamura T;Sakakibara T;Kasai Y;Sudo A
通讯作者：
Sudo A
影响因子：
6.4
作者：
Fang, Jie;Wang, Xin;Wang, Yu
通讯作者：
Wang, Yu
影响因子：
2.9
作者：
Ma, Chao;Wu, Shaoling;Yan, Tiebin
通讯作者：
Yan, Tiebin
影响因子：
3
作者：
Gofeld, Michael;Bristow, Sandee J.;Bollag, Laurent
通讯作者：
Bollag, Laurent
影响因子：
6.3
作者：
Li, L;Wang, HM;Shen, Y
通讯作者：
Shen, Y