Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia.
Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia.
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DOI：
10.1111/apa.14600
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Nelin LD
中科院分区：
文献类型：
--
作者：
Trittmann JK;Bartenschlag A;Zmuda EJ;Frick J;Stewart WCL;Nelin LD
Pulmonary hypertension significantly increases morbidity and mortality in infants with bronchopulmonary dysplasia. The frequency of single nucleotide polymorphisms in arginase-1 (ARG1 rs2781666) and dimethylarginine dimethylaminohydrolase-1 (DDAH1 rs480414) genes have been found to differ in a cohort of bronchopulmonary dysplasia patients with pulmonary hypertension (cases) and without pulmonary hypertension (controls). Therefore, we tested the hypothesis that combining these genotypes with phenotypic data would better predict pulmonary hypertension in bronchopulmonary dysplasia patients. Bronchopulmonary dysplasia patients (n=79) born at <35 weeks gestation were studied. Pulmonary hypertension was diagnosed by echocardiographic criteria (n=20). ROC curves to predict pulmonary hypertension in bronchopulmonary dysplasia were generated from genotype and/or clinical data. Cases were born at an earlier gestation and weighed less at birth than did controls. ROC curves for rs2781666 had an AUC of 0.61, while rs480414 had an AUC of 0.66. Together, the AUC was 0.70. When clinical data was added to the genetic model, AUC was 0.73. These findings demonstrate that ROC predictive modeling of pulmonary hypertension in bronchopulmonary dysplasia improves with inclusion of both genotypic and phenotypic data. Further refinement of these types of models could facilitate the implementation of precision medicine approaches to pulmonary hypertension in bronchopulmonary dysplasia.
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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Trittmann, Jennifer K.;Peterson, Eric;Rogers, Lynette K.;Chen, Bernadette;Backes, Carl H.;Klebanoff, Mark A.;Nelin, Leif D.
通讯作者：
Nelin, Leif D.
DOI：
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发表时间：
2006-02-01
影响因子：
4.9
作者：
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通讯作者：
Nelin, LD
DOI：
10.1111/apa.12717
发表时间：
2014-10
期刊：
Acta paediatrica (Oslo, Norway : 1992)
影响因子：
--
作者：
Trittmann JK;Nelin LD;Zmuda EJ;Gastier-Foster JM;Chen B;Backes CH;Frick J;Vaynshtok P;Vieland VJ;Klebanoff MA
通讯作者：
Klebanoff MA