Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.
Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.
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DOI：
10.1016/j.jpeds.2014.09.004
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发表时间：
2015-02
影响因子：
5.1
通讯作者：
Nelin, Leif D.
中科院分区：
文献类型：
--
作者：
Trittmann, Jennifer K.;Peterson, Eric;Rogers, Lynette K.;Chen, Bernadette;Backes, Carl H.;Klebanoff, Mark A.;Nelin, Leif D.
To test the hypothesis that levels of the endogenous inhibitor of NO production, asymmetric dimethylarginine (ADMA), would be greater in preterm infants with bronchopulmonary dysplasia (BPD) -associated pulmonary hypertension (PH) than in infants with BPD alone. A case control study of 23 patients with both BPD and PH (cases) and 95 patients with BPD but no evidence of PH (controls). Levels of ADMA were compared between cases and controls by t-test. Patients with both BPD and PH have higher plasma levels of ADMA than patients with BPD alone (p=0.04). In samples drawn before 28 days of life, higher levels of ADMA were again found in cases compared with controls (p=0.02). Plasma arginine-to-ADMA ratio was lower in cases than in controls (p=0.03), suggesting a higher likelihood of inhibition of NO production in patients with both BPD and PH than in patients with BPD alone. In this neonatal BPD cohort, ADMA levels are elevated in patients with BPD who develop PH. We speculate that ADMA may be both a biomarker and a potential therapeutic target for preterm infants with BPD-associated PH.
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