Control of bone remodeling by the peripheral sympathetic nervous system.
Control of bone remodeling by the peripheral sympathetic nervous system.
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DOI：
10.1007/s00223-013-9752-4
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发表时间：
2014-01
影响因子：
4.2
通讯作者：
Ma, Yun
中科院分区：
文献类型：
--
作者：
Elefteriou, Florent;Campbell, Preston;Ma, Yun
骨骼不再被视为一个静态的、孤立的、主要是结构性的器官。在过去的二十年里，对骨骼的多重功能有了一个更完整的图景，它与越来越多明显无关的器官的相互作用变得明显。骨骼不仅对机械负荷、炎症、激素和矿物质的挑战做出反应，而且还通过分泌控制其他组织功能的因子自行行动，包括肾脏，可能还有胰腺和性腺。因此，人们越来越广泛地认识到，除了结构器官和矿物质储存和造血场所外，它本质上是一个内分泌器官。因此，根据定义，骨稳态必须被严格调控，并与其他器官的生物学相结合，以维持全身稳态，而揭示中枢神经系统(CNS)参与控制骨重建的数据支持这一概念。交感神经系统(SNs)是连接中枢神经系统和骨骼的主要纽带之一，大量的解剖学、药理学和遗传学研究集中在骨细胞中的肾上腺素能受体(β-adrenerable Receptor，βAR)信号转导方面。这份报告的目的是回顾支持sns和βAR信号在调节骨骼内稳态中的作用的数据。
The skeleton is no longer seen as a static, isolated, and mostly structural organ. Over the last two decades, a more complete picture of the multiple functions of the skeleton has emerged, and its interactions with a growing number of apparently unrelated organs have become evident. The skeleton not only reacts to mechanical loading and inflammatory, hormonal, and mineral challenges, but also acts of its own accord by secreting factors controlling the function of other tissues, including the kidney and possibly the pancreas and gonads. It is thus becoming widely recognized that it is by nature an endocrine organ, in addition to a structural organ and site of mineral storage and hematopoiesis. Consequently and by definition, bone homeostasis must be tightly regulated and integrated with the biology of other organs to maintain whole body homeostasis, and data uncovering the involvement of the central nervous system (CNS) in the control of bone remodeling support this concept. The sympathetic nervous system (SNS) represents one of the main links between the CNS and the skeleton, based on a number of anatomic, pharmacologic, and genetic studies focused on β-adrenergic receptor (βAR) signaling in bone cells. The goal of this report was to review the data supporting the role of the SNS and βAR signaling in the regulation of skeletal homeostasis.
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影响因子：
3.3
作者：
Castañeda-Corral G;Jimenez-Andrade JM;Bloom AP;Taylor RN;Mantyh WG;Kaczmarska MJ;Ghilardi JR;Mantyh PW
通讯作者：
Mantyh PW
影响因子：
45.3
作者：
Barron, Thomas I.;Connolly, Roisin M.;Visvanathan, Kala
通讯作者：
Visvanathan, Kala
神经肽 Y 免疫反应性、酪氨酸羟化酶免疫反应性和血管活性肠多肽 - 骨和周围组织中的免疫反应性神经
DOI：
10.1016/0165-1838(88)90016-1
发表时间：
1988-12-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
BJURHOLM, A;KREICBERGS, A;SCHULTZBERG, M
通讯作者：
SCHULTZBERG, M
咯利普兰 (Rolipram) 是一种磷酸二酯酶 4 抑制剂，通过诱导小鼠锁骨细胞中 TRANCE 表达来刺激破骨细胞形成
影响因子：
6.7
作者：
Cho, ES;Yu, JH;Yim, MJ
通讯作者：
Yim, MJ
β2 激动剂的使用与髋部/股骨骨折的风险：一项基于人群的病例对照研究
影响因子：
2.6
作者：
de Vries, Frank;Pouwels, Sander;van Staa, Tjeerd-Pieter
通讯作者：
van Staa, Tjeerd-Pieter