Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models.
Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models.
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卒中机械血栓清除的临床前测试平台：模体、活体动物和身体模型的综述。
DOI：
10.1136/neurintsurg-2020-017133
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发表时间：
2021-09
影响因子：
4.8
通讯作者：
Savastano L
中科院分区：
文献类型：
--
作者：
Liu Y;Abbasi M;Arturo Larco JL;Kadirvel R;Kallmes DF;Brinjikji W;Savastano L
临床前测试平台在血栓切除器械的研究和开发中发挥了重要作用。然而，没有一个模型可以完全捕获脑血管解剖结构、生理学和动态动脉-凝块-器械相互作用的复杂性。本文对用于血栓切除术测试的体模、体内动物和人体尸体模型进行了严格审查，并深入了解了每个平台的优势和局限性。识别了过去10年发表的报告血栓切除术试验平台的文章。采集每个试验平台的特征，如颅内解剖结构、动脉迂曲度、血管摩擦力、流动条件、器械-血管相互作用和可视化，并以大血管闭塞卒中涉及的人脑血管为基准。血栓切除术模型由硅胶、直接3D打印聚合物和玻璃制成。这些幻影代表了过度简化的患者特定脑血管几何形状，但在适当的流动条件下能够充分可视化器械和凝块。它们不能真实地模拟动脉-凝块相互作用。对于动物模型，已经报道了来自猪、犬和兔的动脉。这些模型能够合理地再现动脉-血栓-器械相互作用，对评价血栓切除器械的安全性具有独特价值。然而，脉管系统的几何形状基本上不那么复杂，并且流动条件与人类脑动脉不同。尸体模型是最准确的血管表示，但在测试条件的再现性方面具有有限的访问和挑战。应可能使用多个试验平台对血栓切除器械进行综合评价。对测试结果的解释应考虑平台特定的限制。
Preclinical testing platforms have been instrumental in the research and development of thrombectomy devices. However, there is no single model which fully captures the complexity of cerebrovascular anatomy, physiology, and the dynamic artery-clot-device interaction. This paper provides a critical review of phantoms, in-vivo animal, and human cadaveric models used for thrombectomy testing and provides insights into the strengths and limitations of each platform. Articles published in the last ten years that reported thrombectomy testing platforms were identified. Characteristics of each test platform, such as intracranial anatomy, artery tortuosity, vessel friction, flow conditions, device-vessel interaction, and visualization, were captured and benchmarked against human cerebral vessels involved in large vessel occlusion stroke. Thrombectomy phantoms have been constructed from silicone, direct 3D-printed polymers, and glass. These phantoms represent oversimplified patient-specific cerebrovascular geometry but enable adequate visualization of devices and clots under appropriate flow conditions. They do not realistically mimic the artery-clot interaction. For the animal models, arteries from swine, canines, and rabbits have been reported. These models can reasonably replicate the artery-clot-device interaction and have the unique value of evaluating the safety of thrombectomy devices. However, the vasculature geometries are substantially less complex and flow conditions are different from human cerebral arteries. Cadaveric models are the most accurate vascular representations but with limited access and challenges in reproducibility of testing conditions. Multiple test platforms should be likely used for comprehensive evaluation of thrombectomy devices. Interpretation of the testing results should take into consideration platform-specific limitations.
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远端栓塞的风险是用支架检索器血栓切除术和适应的风险。
影响因子：
4.8
作者：
Chueh JY;Puri AS;Wakhloo AK;Gounis MJ
通讯作者：
Gounis MJ
体外猪模型评估用于颈总动脉血栓切除术的新型支架取回器。
影响因子：
2.3
作者：
Jiang, Yongjun;Li, Yun;Liu, Xinfeng
通讯作者：
Liu, Xinfeng
影响因子：
4.8
作者：
Brooks, Olivia W.;King, Robert M.;Gounis, Matthew J.
通讯作者：
Gounis, Matthew J.
影响因子：
4.8
作者：
Gounis, Matthew J.;Nogueira, Raul G.;Wakhloo, Ajay K.
通讯作者：
Wakhloo, Ajay K.
DOI：
10.1117/12.2042266
发表时间：
2014-03-13
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
--
作者：
Ionita CN;Mokin M;Varble N;Bednarek DR;Xiang J;Snyder KV;Siddiqui AH;Levy EI;Meng H;Rudin S
通讯作者：
Rudin S