The Gut-Microglia Connection: Implications for Central Nervous System Diseases.
The Gut-Microglia Connection: Implications for Central Nervous System Diseases.
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DOI：
10.3389/fimmu.2018.02325
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发表时间：
2018
影响因子：
7.3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Wang Y;Wang Z;Wang Y;Li F;Jia J;Song X;Qin S;Wang R;Jin F;Kitazato K;Wang Y
肠道微生物组在中枢神经系统（CNS）疾病中的重要性早已被认识到;然而，对这种联系的研究是有限的，部分原因是缺乏令人信服的机制，因为大脑是肠道的遥远目标。先前对大脑的研究表明，大多数受肠道微生物组影响的CNS疾病与小胶质细胞功能障碍密切相关。小胶质细胞是CNS主要的巨噬细胞，对于CNS抵抗感染和损伤的免疫应答以及脑发育和功能至关重要。然而，目前对控制小胶质细胞成熟和功能的机制的理解是模糊的，特别是关于在发育过程中影响小胶质细胞功能的外在因素。肠道微生物群已被证明从出生前到成年期显著影响小胶质细胞，并且微生物群产生的代谢产物调节CNS中小胶质细胞介导的炎症反应;这激发了我们的假设，即小胶质细胞作为肠道微生物组和CNS疾病之间的关键介导者。在此，我们强调并讨论了目前的研究结果，这些研究结果表明宿主微生物组作为一个重要的外在因素对CNS内的小胶质细胞的影响。此外，我们总结了与宿主微生物组和小胶质细胞相关的CNS疾病，并探讨了肠道细菌影响CNS疾病发病机制的潜在途径。因此，我们的工作是一个全面的理论基础，研究在中枢神经系统疾病的发展肠道小胶质细胞连接;并提供了巨大的潜力，为研究人员的目标与肠道小胶质细胞连接相关的途径，克服中枢神经系统疾病。
The importance of the gut microbiome in central nervous system (CNS) diseases has long been recognized; however, research into this connection is limited, in part, owing to a lack of convincing mechanisms because the brain is a distant target of the gut. Previous studies on the brain revealed that most of the CNS diseases affected by the gut microbiome are closely associated with microglial dysfunction. Microglia, the major CNS-resident macrophages, are crucial for the immune response of the CNS against infection and injury, as well as for brain development and function. However, the current understanding of the mechanisms controlling the maturation and function of microglia is obscure, especially regarding the extrinsic factors affecting microglial function during the developmental process. The gut microflora has been shown to significantly influence microglia from before birth until adulthood, and the metabolites generated by the microbiota regulate the inflammation response mediated by microglia in the CNS; this inspired our hypothesis that microglia act as a critical mediator between the gut microbiome and CNS diseases. Herein, we highlight and discuss current findings that show the influence of host microbiome, as a crucial extrinsic factor, on microglia within the CNS. In addition, we summarize the CNS diseases associated with both the host microbiome and microglia and explore the potential pathways by which the gut bacteria influence the pathogenesis of CNS diseases. Our work is thus a comprehensive theoretical foundation for studies on the gut-microglia connection in the development of CNS diseases; and provides great potential for researchers to target pathways associated with the gut-microglia connection and overcome CNS diseases.
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影响因子：
16.6
作者：
Arno, Benedetta;Grassivaro, Francesca;Muzio, Luca
通讯作者：
Muzio, Luca
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ
DOI：
10.1073/pnas.0711891105
发表时间：
2008-02-12
影响因子：
11.1
作者：
Amaral, F. A.;Sachs, D.;Teixeira, M. M.
通讯作者：
Teixeira, M. M.
宿主微生物群调节小鼠社会偏好的发展。
影响因子：
--
作者：
Arentsen T;Raith H;Qian Y;Forssberg H;Diaz Heijtz R
通讯作者：
Diaz Heijtz R
影响因子：
--
作者：
Asiimwe N;Yeo SG;Kim MS;Jung J;Jeong NY
通讯作者：
Jeong NY