Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.
Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.
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DOI：
10.1038/s41398-022-02085-8
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发表时间：
2022-08-08
影响因子：
6.8
通讯作者：
Stevens, Jennifer S.
中科院分区：
文献类型：
--
作者：
Harnett, Nathaniel G.;Finegold, Katherine E.;Lebois, Lauren A. M.;van Rooij, Sanne J. H.;Ely, Timothy D.;Murty, Vishnu P.;Jovanovic, Tanja;Bruce, Steven E.;House, Stacey L.;Beaudoin, Francesca L.;An, Xinming;Zeng, Donglin;Neylan, Thomas C.;Clifford, Gari D.;Linnstaedt, Sarah D.;Germine, Laura T.;Bollen, Kenneth A.;Rauch, Scott L.;Haran, John P.;Storrow, Alan B.;Lewandowski, Christopher;Musey, Paul, I;Hendry, Phyllis L.;Sheikh, Sophia;Jones, Christopher W.;Punches, Brittany E.;Kurz, Michael C.;Swor, Robert A.;Hudak, Lauren A.;Pascual, Jose L.;Seamon, Mark J.;Harris, Erica;Chang, Anna M.;Pearson, Claire;Peak, David A.;Domeier, Robert M.;Rathlev, Niels K.;O'Neil, Brian J.;Sergot, Paulina;Sanchez, Leon D.;Miller, Mark W.;Pietrzak, Robert H.;Joormann, Jutta;Barch, Deanna M.;Pizzagalli, Diego A.;Sheridan, John F.;Harte, Steven E.;Elliott, James M.;Kessler, Ronald C.;Koenen, Karestan C.;McLean, Samuel A.;Nickerson, Lisa D.;Ressler, Kerry J.;Stevens, Jennifer S.
创伤记忆的视觉成分经常被幸存者生动地重新体验，对正常功能造成有害后果。关于创伤的神经成像研究主要集中在威胁处理回路作为创伤相关功能障碍的核心。相反，对视觉回路的关注有限，这可能与创伤后应激障碍(PTSD)特别相关。先前的工作表明，腹侧视觉流与创伤后应激障碍中观察到的认知和情感障碍直接相关，并可能预测后来的症状表达。这项研究使用了创伤暴露两周后从奥罗拉研究中收集的多模式磁共振成像数据(n = 278)，这是一项关于创伤后神经精神后遗症的纵向、多点调查。用数据融合技术将灰质和白质指数结合起来，以确定创伤后2周腹侧视流的结构协方差网络(SCN)。参与者在SCN上的负荷与侵扰症状和噩梦的强度都呈正相关。此外，SCN负荷缓和了先前观察到的杏仁核-海马区功能协方差网络和下颞回之间的连接。随访6个月的MRI数据显示，SCN负荷与情绪认知的负面变化呈负相关。此外，在2周至6个月期间表现出SCN强度降低的个体，随着时间的推移，通常有更高的PTSD症状严重程度。目前的研究结果强调了腹侧视流的结构完整性在创伤后应激障碍的发展中的作用。腹侧视觉流对于创伤记忆的巩固或恢复可能特别重要，并可能有助于有效地重新激活创伤记忆的视觉成分，从而加剧创伤后应激障碍症状。潜在的长期参与网络可能会导致结构完整性降低，这成为持久的创伤后应激障碍症状的风险因素。
Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on trauma has primarily focused on threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention has been given to visual circuitry which may be particularly relevant to posttraumatic stress disorder (PTSD). Prior work suggests that the ventral visual stream is directly related to the cognitive and affective disturbances observed in PTSD and may be predictive of later symptom expression. The present study used multimodal magnetic resonance imaging data (n = 278) collected two weeks after trauma exposure from the AURORA study, a longitudinal, multisite investigation of adverse posttraumatic neuropsychiatric sequelae. Indices of gray and white matter were combined using data fusion to identify a structural covariance network (SCN) of the ventral visual stream 2 weeks after trauma. Participant’s loadings on the SCN were positively associated with both intrusion symptoms and intensity of nightmares. Further, SCN loadings moderated connectivity between a previously observed amygdala-hippocampal functional covariance network and the inferior temporal gyrus. Follow-up MRI data at 6 months showed an inverse relationship between SCN loadings and negative alterations in cognition in mood. Further, individuals who showed decreased strength of the SCN between 2 weeks and 6 months had generally higher PTSD symptom severity over time. The present findings highlight a role for structural integrity of the ventral visual stream in the development of PTSD. The ventral visual stream may be particularly important for the consolidation or retrieval of trauma memories and may contribute to efficient reactivation of visual components of the trauma memory, thereby exacerbating PTSD symptoms. Potentially chronic engagement of the network may lead to reduced structural integrity which becomes a risk factor for lasting PTSD symptoms.
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影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
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作者：
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通讯作者：
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影响因子：
4.8
作者：
Fani, Negar;Michopoulos, Vasiliki;Stevens, Jennifer S.
通讯作者：
Stevens, Jennifer S.
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.